| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 41806; FAM14C; G1P3; Ifi-6-16; IFI6 |
| Entrez GeneID | 2537; |
| WB Predicted band size | 13kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human IFI6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IFI6抗体的3篇代表性文献摘要(虚拟示例)：
1. **文献名称**: "IFI6 mediates viral resistance through suppression of mitochondrial apoptosis"
**作者**: Smith A, et al. (2022)
**摘要**: 本研究利用特异性IFI6抗体(货号ABX-123)验证了该蛋白在HCV感染中的抗凋亡作用。Western blot及免疫荧光显示IFI6抑制线粒体途径Caspase激活，抗体特异性经siRNA敲除验证，为抗病毒治疗提供新靶点。
2. **文献名称**: "Development and validation of a novel IFI6 monoclonal antibody for breast cancer diagnostics"
**作者**: Chen L, et al. (2021)
**摘要**: 文章报道了鼠源单抗4D2的制备(IgG1κ型)，通过肽阵列和流式细胞术验证其特异性。该抗体成功应用于乳腺癌组织芯片(IHC)，显示IFI6高表达与患者生存率负相关。
3. **文献名称**: "Interferon-induced IFI6 regulates endoplasmic reticulum stress in hepatocellular carcinoma"
**作者**: Tanaka K, et al. (2020)
**摘要**: 使用兔多抗(CellSig#6789)研究发现，IFI6通过结合GRP78缓解内质网应激，促进肝癌细胞存活。抗体经CRISPR敲除细胞系验证特异性，免疫共沉淀揭示其分子互作机制。
注：以上文献信息为示例性质，实际引用需查询具体数据库。建议通过PubMed搜索关键词"IFI6 antibody"筛选应用性研究，优先选择包含抗体验证细节(如基因敲除验证、货号信息)的论文。
The interferon alpha-inducible protein 6 (IFI6), also known as G1P3. is a small, highly conserved protein encoded by the IFI6 gene, part of the interferon-stimulated gene (ISG) family. It is robustly induced by type I interferons (IFNs) during viral infections, inflammation, or cellular stress, playing a role in modulating apoptosis and promoting cell survival. IFI6 is localized to mitochondria and inhibits intrinsic apoptosis by interacting with pro-apoptotic proteins like BAX, preventing mitochondrial outer membrane permeabilization. This anti-apoptotic function helps cells survive inflammatory or immune responses triggered by IFN signaling.
IFI6 antibodies are essential tools for detecting and quantifying IFI6 expression in research contexts, such as studying viral-host interactions, cancer biology, and autoimmune diseases. Overexpression of IFI6 has been observed in certain cancers (e.g., breast, ovarian), correlating with poor prognosis and chemoresistance, suggesting its potential as a therapeutic target or biomarker. Conversely, IFI6 deficiency may enhance apoptosis under stress conditions. Antibodies against IFI6 enable techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in elucidating its regulatory mechanisms and pathophysiological roles. Research on IFI6 continues to explore its dual role in balancing cell survival and death during immune challenges.
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