| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IFIT-5; interferon-induced protein with tetratricopeptide repeats 5; retinoic acid- and interferon-inducible 58 kDa protein; RI58; |
| Entrez GeneID | 24138; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human IFIT5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IFIT5抗体的3篇参考文献示例(注意：文献信息为模拟概括，实际引用请根据真实文献调整)：
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1. **文献名称**: *"Interferon-induced protein IFIT5 inhibits Ebola virus replication through binding to viral NP protein"*
**作者**: Wang Y, et al.
**摘要**: 本研究利用IFIT5特异性抗体进行免疫共沉淀实验，发现IFIT5通过直接结合埃博拉病毒核蛋白(NP)抑制病毒复制，揭示了IFIT5在抗病毒天然免疫中的分子机制。
2. **文献名称**: *"IFIT5 expression is regulated by IRF3 and antiviral response in zebrafish"*
**作者**: Chen J, et al.
**摘要**: 通过Western blot和免疫荧光技术(使用兔源多克隆IFIT5抗体)，作者证明斑马鱼IFIT5在病毒刺激后依赖IRF3通路表达上调，提示其在脊椎动物抗病毒防御中的保守功能。
3. **文献名称**: *"Development of a monoclonal antibody against human IFIT5 for diagnostic applications"*
**作者**: Liu X, et al.
**摘要**: 该研究成功制备了一种高特异性小鼠抗人IFIT5单克隆抗体，验证了其在ELISA、免疫组化中的应用，为癌症和病毒感染中IFIT5的检测提供了新工具。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“IFIT5 antibody”或“IFIT5 + 研究主题(如病毒、癌症等)”获取最新研究。
The IFIT5 antibody targets interferon-induced protein with tetratricopeptide repeats 5 (IFIT5), a member of the IFIT family critical in innate antiviral immunity. IFIT5. also known as ISG58. is encoded by an interferon-stimulated gene (ISG) and contains multiple tetratricopeptide repeat (TPR) motifs that mediate protein-protein interactions. It plays a role in restricting viral replication by binding to viral RNA, particularly those lacking 2′-O methylation, a common feature of many RNA viruses (e.g., influenza, coronaviruses). IFIT5 is upregulated by type I interferons (IFN-α/β) during viral infections, acting as a sensor to inhibit viral translation or recruit immune effectors.
Antibodies against IFIT5 are essential tools for studying its expression, localization, and interactions in viral infections, immune signaling, and autoimmune or inflammatory diseases. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect IFIT5 in cell lines, tissues, or clinical samples. Species-specific antibodies (e.g., human, mouse) are available, with monoclonal antibodies offering high specificity and polyclonal antibodies providing broader epitope recognition. Research using IFIT5 antibodies has advanced understanding of its antiviral mechanisms, host-pathogen interactions, and potential roles in cancer progression. Validated antibodies are critical to ensure accurate detection, given the homology between IFIT family members and their context-dependent expression patterns.
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