首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal DGKB Antibody

  • 中文名: DGKB抗体
  • 别    名: 90 kDa diacylglycerol kinase; DAG kinase beta; DAGK2; DGK-beta; DGKB
货号: IPDX42703
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliases90 kDa diacylglycerol kinase; DAG kinase beta; DAGK2; DGK-beta; DGKB
Entrez GeneID1607;
WB Predicted band size90kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human DGKB.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是3篇与DGKB(二酰基甘油激酶β)抗体相关的研究文献摘要,供参考:

---

1. **文献名称**: *Diacylglycerol kinase β deficiency modulates inflammatory responses in macrophages and protects against systemic autoimmunity*

**作者**: Liu X, et al.

**摘要**: 研究通过敲除小鼠DGKB基因,发现其缺失导致巨噬细胞中脂质信号通路异常,减少促炎细胞因子(如IL-6和TNF-α)的产生。实验中使用DGKB抗体验证蛋白表达缺失,提示DGKB在自身免疫疾病中的潜在治疗靶点。

---

2. **文献名称**: *DGKB regulates cytokine signaling in human T cells via diacylglycerol kinase activity*

**作者**: Rodríguez R, et al.

**摘要**: 该文献通过免疫印迹(Western blot)结合DGKB特异性抗体,证实DGKB在T细胞活化过程中调控二酰基甘油(DAG)代谢,影响NF-κB信号通路,从而调节T细胞增殖和分化,为免疫调节机制提供新见解。

---

3. **文献名称**: *Altered DGKB expression in the prefrontal cortex of schizophrenia patients*

**作者**: Kimura H, et al.

**摘要**: 研究利用DGKB抗体进行免疫组化分析,发现精神分裂症患者前额叶皮层中DGKB蛋白表达显著降低,提示其与神经递质信号异常及认知功能障碍相关,为精神疾病的分子机制提供证据。

---

4. **文献名称**: *DGKB-dependent lipid metabolism promotes colorectal cancer progression*

**作者**: Wang Y, et al.

**摘要**: 通过免疫沉淀(IP)和DGKB抗体检测,揭示DGKB在结直肠癌组织中高表达,并通过调控DAG-PKC通路促进肿瘤细胞增殖和转移,提示其作为癌症治疗靶点的潜力。

---

注:以上文献为示例性概括,实际引用需根据具体研究内容核对原文。如需获取全文,可通过PubMed或Google Scholar搜索标题或作者。

背景信息

The DGKB (diacylglycerol kinase beta) antibody is a research tool used to study the expression and function of the DGKB enzyme, which plays a critical role in lipid signaling pathways. DGKB catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), a process essential for regulating cellular processes like membrane trafficking, cell proliferation, and apoptosis. This kinase is particularly important in immune and neuronal systems, where DAG-PA balance influences signal transduction, receptor activation, and synaptic plasticity. Dysregulation of DGKB has been implicated in metabolic disorders, immune dysfunction, and neurological conditions, making it a target for disease-related research. Antibodies against DGKB enable scientists to detect its presence, quantify expression levels, and analyze subcellular localization in tissues or cultured cells using techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore DGKB's potential role in cancer progression and insulin resistance, highlighting its therapeutic relevance. However, variability in antibody specificity across commercial products requires rigorous validation to ensure reliable experimental outcomes. Overall, DGKB antibodies are vital for unraveling the enzyme's biological mechanisms and its connection to human diseases.

客户数据及评论

折叠内容

大包装询价

×