| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LIFR; SWS; SJS2; STWS; LIF-R |
| Entrez GeneID | 3977 |
| clone | 5D3G12 |
| WB Predicted band size | 123.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PLA2G7 (AA: 22-441) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SLC30A9抗体的模拟参考文献示例(实际文献可能需要通过学术数据库进一步检索确认)：
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1. **文献名称**: "SLC30A9 regulates vesicular zinc storage and neuronal excitability"
**作者**: Smith J, et al.
**摘要**: 研究利用SLC30A9特异性抗体，通过免疫组化和Western blot技术，揭示了该蛋白在小鼠脑神经元囊泡锌储存中的关键作用，并发现其缺失导致突触传递异常。
2. **文献名称**: "Development and validation of a monoclonal antibody targeting human SLC30A9 for diagnostic applications"
**作者**: Lee S, Kim D.
**摘要**: 描述了针对人源SLC30A9的单克隆抗体制备过程，通过质谱和siRNA敲低实验验证其特异性，并应用于癌症组织样本中锌转运蛋白的检测。
3. **文献名称**: "Zinc transporter SLC30A9 modulates β-cell insulin secretion"
**作者**: Garcia-Ruiz C, et al.
**摘要**: 使用SLC30A9抗体发现其在胰岛β细胞中的高表达，通过敲减实验证明其通过调控锌离子浓度影响胰岛素分泌，提示与糖尿病病理相关。
4. **文献名称**: "SLC30A9 deficiency disrupts lysosomal zinc homeostasis and promotes neurodegeneration"
**作者**: Wang Y, et al.
**摘要**: 基于SLC30A9抗体检测，发现该蛋白定位于溶酶体膜，其缺失导致溶酶体锌积累和神经元死亡，为神经退行性疾病机制提供了新见解。
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**备注**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台以关键词“SLC30A9 antibody”或“ZnT9”(SLC30A9别名)检索。建议结合工具如ZINC数据库或抗体公司(如Abcam、Sigma-Aldrich)的产品引用文献获取具体信息。
SLC30A9 antibody targets the solute carrier family 30 member 9 (SLC30A9), a protein encoded by the SLC30A9 gene. This protein belongs to the SLC30A zinc transporter family, which plays a critical role in cellular zinc homeostasis by regulating zinc efflux from the cytoplasm into intracellular organelles or extracellular spaces. SLC30A9 is broadly expressed in various tissues, including the brain, pancreas, and kidneys, and is localized to intracellular membranes, particularly in the endosomes and Golgi apparatus. It is implicated in maintaining zinc balance, which is essential for enzymatic functions, signal transduction, and cellular metabolism.
Antibodies against SLC30A9 are widely used in research to study its expression, localization, and biological functions. They are critical tools for techniques like Western blotting, immunohistochemistry, and immunofluorescence, enabling the visualization of SLC30A9 protein levels and distribution in different cell types or tissues. Such studies have linked SLC30A9 to neurological processes, insulin secretion, and cellular stress responses. Dysregulation of zinc transport mediated by SLC30A9 has been associated with neurodegenerative disorders, diabetes, and cancer, making this antibody valuable for exploring disease mechanisms. Researchers often validate SLC30A9 antibodies using knockout controls or siRNA knockdown to ensure specificity. Commercial antibodies are typically raised in rabbits or mice, with applications optimized for human, mouse, or rat samples.
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