| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CD212; IL12RB; IL-12R-BETA1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human IL12RB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDY1抗体的3篇参考文献的模拟示例(内容基于学术领域常见研究方向合理推测，非真实文献)：
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1. **文献名称**: *CDY1. a novel Y-chromosome-encoded chromatin remodeling protein in mammalian spermatogenesis*
**作者**: Lahn BT, et al.
**摘要**: 本研究通过筛选Y染色体特异性基因，鉴定了CDY1蛋白在精子发生中的作用。作者开发了兔源多克隆CDY1抗体，并利用免疫组化技术证实CDY1在减数分裂后精子细胞中高表达，提示其可能通过调控组蛋白乙酰化参与染色质浓缩过程。
2. **文献名称**: *Characterization of CDY1 as a chromatin modifier in human somatic and germ cells*
**作者**: Aran B, et al.
**摘要**: 该研究利用小鼠单克隆CDY1抗体(克隆号：2C8)进行Western blot和免疫荧光分析，发现CDY1不仅在睾丸生殖细胞中表达，也在部分体细胞中参与DNA损伤修复。抗体特异性验证显示其与CDY1蛋白C端结构域特异性结合。
3. **文献名称**: *Dysregulation of CDY1 expression correlates with male infertility*
**作者**: Kleiman SE, et al.
**摘要**: 通过抗CDY1抗体(山羊多克隆，Abcam ab12345)对不育患者精子样本进行检测，发现CDY1蛋白表达水平显著降低。研究表明，CDY1抗体可作为评估精子染色质完整性的潜在生物标志物。
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注：上述文献信息为示例性质，实际研究中需通过PubMed、Google Scholar等平台检索真实文献。若需具体文献，建议补充实验背景或抗体应用场景。
The CDY1 (Chromodomain Protein Y-Linked 1) antibody is a tool used to study the CDY1 protein, a chromatin-associated factor implicated in spermatogenesis and male fertility. CDY1 is encoded by the *CDY1* gene located on the Y chromosome, making it male-specific. The protein contains a chromodomain, a conserved structural motif that facilitates interactions with methylated histone residues, suggesting its role in epigenetic regulation. CDY1 is expressed predominantly in the testes, particularly in post-meiotic germ cells, where it participates in chromatin remodeling during spermiogenesis. This process involves histone-to-protamine replacement, crucial for sperm head condensation and genome stability.
CDY1 antibodies are utilized in research to investigate its expression patterns, subcellular localization, and interactions with other chromatin-modifying proteins (e.g., histone acetyltransferases). These studies have linked CDY1 dysfunction to male infertility, as mutations or deletions in the *CDY1* gene correlate with abnormal sperm morphology and impaired fertility. Additionally, CDY1 antibodies aid in exploring its potential role in germ cell tumors and other reproductive disorders.
As part of the CDY family, which includes autosomal paralogs like CDYL and CDYL2. CDY1’s unique Y-chromosome localization underscores its evolutionary specialization in male reproductive biology. The antibody’s applications span immunohistochemistry, Western blotting, and immunofluorescence, contributing to both basic research and clinical diagnostics in andrology.
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