Rabbit Polyclonal STARD1 Antibody

STARD1 (STeroidogenic Acute Regulatory protein-Related lipid Transfer Domain-containing protein 1), also known as StAR, is a mitochondrial protein critical for cholesterol transport, the rate-limiting step in steroid hormone biosynthesis. It facilitates the transfer of cholesterol from the outer to inner mitochondrial membrane, enabling its conversion into pregnenolone by cytochrome P450scc. This process is essential for producing glucocorticoids, mineralocorticoids, and sex hormones in adrenal glands, gonads, and placental tissues. STARD1 antibodies are vital tools in studying steroidogenic tissues, enabling detection and localization of StAR protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulated STARD1 is linked to disorders such as congenital adrenal hyperplasia (CAH), lipoid adrenal hyperplasia, and polycystic ovary syndrome (PCOS). Researchers use these antibodies to explore molecular mechanisms in steroidogenesis, genetic mutations affecting StAR function, and potential therapeutic targets. Their specificity also aids in distinguishing steroidogenic deficiencies from other endocrine pathologies. By analyzing StAR expression patterns, scientists gain insights into tissue-specific steroid regulation and metabolic adaptations under physiological or stress conditions.