Rabbit Polyclonal ARX Antibody

ARX (Aristaless-related homeobox) antibodies are essential tools in studying the role of the ARX protein, a transcription factor critical for embryonic development, particularly in the brain and reproductive organs. The ARX gene, located on the X chromosome, regulates gene expression during neurogenesis, neuronal migration, and differentiation. Mutations in ARX are linked to severe neurodevelopmental disorders, including X-linked lissencephaly, intellectual disability, and epilepsy syndromes. ARX antibodies enable researchers to detect and localize the protein in tissues or cells, aiding investigations into its expression patterns and functional mechanisms. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to explore ARX's involvement in developmental pathways and disease pathology. Studies using ARX-deficient animal models have highlighted its role in GABAergic interneuron development and cortical circuit formation. Commercially available ARX antibodies are typically raised against specific epitopes of the protein, with validation in knockout controls to ensure specificity. Their application extends to clinical research, helping correlate ARX expression anomalies with patient phenotypes. Ongoing research leveraging these antibodies continues to unravel ARX's regulatory networks, offering insights into potential therapeutic targets for ARX-related disorders.