| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 329; ZNF329; |
| Entrez GeneID | 79673; |
| WB Predicted band size | 61kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ZNF329. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF329抗体的模拟参考文献示例(注：部分内容为假设性概括，建议通过学术数据库验证具体文献)：
1. **《ZNF329 regulates cell proliferation in hepatocellular carcinoma through the Wnt/β-catenin pathway》**
- **作者**: Li X, et al.
- **摘要**: 本研究利用ZNF329抗体进行免疫印迹和免疫组化实验，发现ZNF329在肝癌组织中表达下调，并通过抑制Wnt/β-catenin信号通路抑制肿瘤细胞增殖。
2. **《ZNF329 modulates antiviral responses by interacting with interferon regulatory factors》**
- **作者**: Wang Y, et al.
- **摘要**: 通过ZNF329抗体的染色质免疫沉淀(ChIP)分析，揭示了ZNF329与IRF3/7结合，负调控I型干扰素的表达，影响宿主抗病毒免疫反应。
3. **《A novel role of ZNF329 in maintaining genomic stability during DNA repair》**
- **作者**: Chen H, et al.
- **摘要**: 使用ZNF329抗体的免疫荧光实验显示，ZNF329在DNA损伤位点富集，通过促进同源重组修复维持基因组稳定性，其缺失导致细胞对辐射敏感性增加。
4. **《ZNF329-mediated transcriptional repression of oncogenic miRNAs in breast cancer》**
- **作者**: Gupta S, et al.
- **摘要**: 通过ZNF329抗体的功能研究，发现其通过结合特定miRNA启动子区域(如miR-21)，抑制肿瘤相关miRNA表达，从而抑制乳腺癌转移。
**提示**：以上文献名为假设性示例，实际研究需通过PubMed、Web of Science等平台以“ZNF329 antibody”及相关关键词检索确认。
**Background of ZNF329 Antibody**
ZNF329 (Zinc Finger Protein 329) is a member of the zinc finger protein family, characterized by conserved C2H2-type zinc finger domains that facilitate DNA or RNA binding. This protein is hypothesized to function as a transcriptional regulator, potentially influencing gene expression by interacting with specific nucleic acid sequences or chromatin-modifying complexes. While its precise biological role remains under investigation, ZNF329 has been implicated in cellular processes such as proliferation, differentiation, and apoptosis, with emerging links to cancer progression and other diseases.
Antibodies targeting ZNF329 are essential tools for studying its expression, localization, and molecular interactions. These antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments derived from ZNF329's unique regions. Validated applications include Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specificity is often confirmed using knockout cell lines or siRNA-mediated knockdown controls.
Research utilizing ZNF329 antibodies has contributed to mapping its tissue distribution, revealing elevated expression in certain cancers, and exploring its regulatory networks. However, challenges persist in fully elucidating its mechanistic roles and clinical relevance. Ongoing studies aim to clarify ZNF329's involvement in epigenetic regulation, disease pathways, and potential therapeutic targeting, underscoring the antibody's importance in advancing molecular and translational research.
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