Rabbit Polyclonal MED27 Antibody

The MED27 antibody is a crucial tool for studying the Mediator Complex subunit 27. a component of the multi-protein Mediator Complex essential for regulating RNA polymerase II (Pol II)-mediated transcription. The Mediator Complex acts as a molecular bridge, facilitating communication between transcription factors and the core transcriptional machinery. MED27. a subunit within the Mediator’s “head” module, plays roles in transcriptional initiation, elongation, and chromatin modification. Dysregulation of MED27 has been linked to diseases, including cancers and neurological disorders. For instance, studies suggest its involvement in tumor progression via oncogenic pathways and in neurodevelopment due to interactions with neuronal transcription factors. MED27 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions in cellular and tissue samples. Researchers employ these antibodies to explore MED27’s functional mechanisms in gene regulation, its association with disease pathways, and potential therapeutic targets. Recent investigations also highlight its role in maintaining cellular homeostasis and stress responses. However, variability in antibody specificity and cross-reactivity across species or isoforms requires careful validation in experimental settings. Overall, MED27 antibodies are vital for unraveling the Mediator Complex’s intricate roles in health and disease.