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Rabbit Polyclonal ZNF46 Antibody

  • 中文名: ZNF46抗体
  • 别    名: HZF8; zinc finger protein 272; zinc finger protein HZF8; ZN272; ZN460
货号: IPDX42673
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHZF8; zinc finger protein 272; zinc finger protein HZF8; ZN272; ZN460
Entrez GeneID10794;
WB Predicted band size64kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human ZNF460.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是基于ZNF46抗体的**模拟参考文献示例**(请注意,ZNF46相关研究较为小众,实际文献需通过PubMed/Google Scholar等平台验证):

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1. **标题**:Zinc Finger Protein ZNF46 as a Potential Biomarker in Glioblastoma

**作者**:Smith A, et al.

**摘要**:本研究通过ZNF46抗体进行免疫组化分析,发现ZNF46在胶质母细胞瘤组织中高表达,且与患者预后不良相关,提示其可能作为肿瘤治疗的靶点。

2. **标题**:Characterization of ZNF46 Antibody Specificity in Neural Development

**作者**:Chen L, et al.

**摘要**:验证了ZNF46抗体的特异性,并发现ZNF46在小鼠大脑发育过程中动态表达,可能通过调控突触相关基因影响神经元分化。

3. **标题**:ZNF46 Regulates Inflammatory Response via NF-κB Pathway

**作者**:Wang X, et al.

**摘要**:利用ZNF46抗体进行ChIP-seq和Western blot实验,证明ZNF46通过抑制NF-κB通路减轻巨噬细胞的炎症反应,为自身免疫疾病机制提供新见解。

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**说明**:

- 以上为示例文献,实际研究中ZNF46抗体相关论文较少,建议通过关键词“ZNF46 antibody”或“ZNF46 (Zinc Finger Protein 46)”在学术数据库中检索最新文献。

- 部分研究可能以ZNF46的别名(如ZKSCAN5)命名,需注意术语差异。

背景信息

The ZNF46 antibody targets the zinc finger protein 46 (ZNF46), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (KZNF) family. These proteins are characterized by tandem C2H2 zinc finger motifs and a KRAB domain, which mediates interactions with transcriptional co-repressors. ZNF46. also known as ZNF134. is implicated in transcriptional regulation, potentially repressing gene expression by recruiting chromatin-modifying complexes. Its expression is observed in various tissues, though functional studies remain limited. The ZNF46 antibody is a critical tool for investigating the protein's localization, expression levels, and molecular interactions in cellular contexts. Researchers utilize it in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore ZNF46's role in development, cellular differentiation, and disease pathways, including cancer and neurological disorders. Commercial ZNF46 antibodies are typically developed in hosts like rabbits or mice, with validation steps (e.g., knockout controls) to ensure specificity. Ongoing research aims to clarify ZNF46's precise biological functions and its potential as a biomarker or therapeutic target.

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