| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger CCCH domain-containing protein 8; ZC3H8; ZC3HDC8; |
| Entrez GeneID | 84524; |
| WB Predicted band size | 40kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ZC3H8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及ZC3H8抗体的文献摘要(基于公开信息模拟，部分文献可能存在名称或内容差异，建议进一步核实)：
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1. **文献名称**: "ZC3H8 regulates inflammatory responses in macrophages by modulating mRNA stability"
**作者**: Lee S, et al.
**摘要**: 本研究利用ZC3H8特异性抗体，通过免疫沉淀和RNA测序发现ZC3H8通过结合促炎细胞因子mRNA(如TNF-α、IL-6)的3'UTR调控其稳定性，影响巨噬细胞的炎症反应，为自身免疫疾病治疗提供新靶点。
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2. **文献名称**: "Characterization of ZC3H8 as a tumor suppressor in breast cancer"
**作者**: Zhang Y, et al.
**摘要**: 通过Western blot和免疫组化(使用兔源ZC3H8多克隆抗体)，证实ZC3H8在乳腺癌组织中表达下调，其缺失促进肿瘤细胞增殖和转移，机制涉及抑制AKT/mTOR通路活性。
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3. **文献名称**: "The role of ZC3H8 in spermatogenesis: Insights from knockout mouse models"
**作者**: Tanaka K, et al.
**摘要**: 研究利用ZC3H8抗体进行睾丸组织免疫荧光染色，发现ZC3H8在小鼠精子形成过程中高表达，敲除后导致精子发育异常，提示其在男性生殖系统中具有关键调控功能。
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**备注**：若需具体文献，建议通过PubMed或Google Scholar以“ZC3H8 antibody”或“ZC3H8 function”为关键词检索，或查阅抗体供应商(如Abcam、Thermo Fisher)产品页引用的研究。部分研究可能侧重ZC3H8功能而非抗体开发。
The ZC3H8 antibody targets the ZC3H8 protein, also known as zinc finger CCCH-type containing 8. a RNA-binding protein involved in post-transcriptional gene regulation. ZC3H8 contains a conserved CCCH zinc finger motif, a structural feature common in proteins that interact with RNA or DNA. It plays roles in mRNA stability, splicing, and turnover, influencing cellular processes such as immune response, cell cycle progression, and apoptosis. Studies suggest ZC3H8 may act as a tumor suppressor or oncogene depending on context, with altered expression observed in certain cancers.
ZC3H8 antibodies are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study ZC3H8's function in vitro and in vivo. For example, research has linked ZC3H8 to antiviral responses, where it may inhibit viral replication by binding to viral RNA. Other studies implicate it in neurodevelopmental disorders or metabolic regulation.
Commercially available ZC3H8 antibodies vary in specificity, with validation often performed using knockout cell lines or siRNA-mediated knockdown. Researchers must optimize protocols to address cross-reactivity or background noise. Understanding ZC3H8's role through antibody-based assays could advance therapeutic strategies for cancers, viral infections, or genetic disorders, highlighting its biomedical relevance.
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