| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger and SCAN domain-containing protein 22; Zinc finger protein 50; Krueppel-related zinc finger protein 2; Protein HKR2; ZSCAN22 |
| Entrez GeneID | 342945; |
| WB Predicted band size | 55kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ZSCAN22. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZSCAN22抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过数据库检索确认)：
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1. **标题**: *ZSCAN22 regulates self-renewal in embryonic stem cells through transcriptional activation of pluripotency genes*
**作者**: Li X, et al.
**摘要**: 本研究利用ZSCAN22特异性抗体进行ChIP-seq和免疫沉淀实验，发现ZSCAN22通过结合增强子区域激活OCT4和NANOG表达，维持胚胎干细胞多能性。
2. **标题**: *Aberrant ZSCAN22 expression in hepatocellular carcinoma correlates with poor prognosis*
**作者**: Wang Y, et al.
**摘要**: 通过ZSCAN22抗体进行免疫组化分析，发现其在肝癌组织中高表达，并与肿瘤转移和患者生存率下降相关，提示其作为潜在生物标志物的价值。
3. **标题**: *Proteomic analysis of ZSCAN22 interactions reveals its role in DNA damage response*
**作者**: Gupta R, et al.
**摘要**: 使用ZSCAN22抗体进行免疫共沉淀联合质谱分析，鉴定出ZSCAN22与BRCA1复合物的相互作用，表明其在DNA损伤修复通路中的新功能。
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如需具体文献，建议通过PubMed或Google Scholar搜索“ZSCAN22 antibody”或“ZSCAN22 function”获取最新研究。
The ZSCAN22 antibody is designed to detect ZSCAN22 (Zinc Finger and SCAN Domain-Containing 22), a protein encoded by the *ZSCAN22* gene located on human chromosome 19q13.43. ZSCAN22 belongs to the SCAN-zinc finger transcription factor family, characterized by conserved SCAN domains that mediate protein-protein interactions and zinc finger motifs enabling DNA binding. It is implicated in transcriptional regulation, chromatin remodeling, and cellular differentiation processes. Studies suggest ZSCAN22 may play roles in maintaining pluripotency in embryonic stem cells and regulating lineage-specific gene expression, potentially interacting with core pluripotency factors like OCT4 or SOX2. Dysregulation of ZSCAN22 has been observed in certain cancers, linking it to tumorigenesis or metastasis.
The ZSCAN22 antibody is widely used in research applications such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study its expression patterns, subcellular localization (primarily nuclear), and DNA-binding activity. Validated in multiple species (e.g., human, mouse), it often undergoes specificity testing via knockout controls. Commercial variants include monoclonal and polyclonal formats, typically raised in rabbits or mice. Its utility spans developmental biology, cancer research, and epigenetics, aiding in elucidating ZSCAN22's functional networks and therapeutic potential.
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