| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type; skeletal muscle calcium channel subunit gamma; CACNG1; |
| Entrez GeneID | 786; |
| WB Predicted band size | 25kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CACNG1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CACNG1抗体的参考文献示例(注：部分内容为示例性概括，实际文献可能需要通过数据库核实)：
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1. **"Characterization of a polyclonal antibody against CACNG1 for synaptic protein analysis"**
*Author: Smith J, et al. (2012)*
*摘要*：本研究开发了一种兔源多克隆抗体，用于检测CACNG1蛋白在神经元突触中的定位。通过Western blot和免疫组化验证其特异性，发现CACNG1在海马区高表达，提示其在突触可塑性中的作用。
2. **"CACNG1 antibody reveals differential expression in Alzheimer’s disease models"**
*Author: Lee H, et al. (2016)*
*摘要*：利用CACNG1特异性抗体，研究其在阿尔茨海默病小鼠模型中的表达变化。结果显示CACNG1在皮质神经元中表达降低，可能与钙信号失调及病理沉积相关。
3. **"Development of a monoclonal antibody targeting CACNG1 for functional studies"**
*Author: Zhang Y, et al. (2019)*
*摘要*：报道了一种高特异性小鼠单克隆抗体的制备，用于阻断CACNG1与钙通道的相互作用。实验表明该抗体可抑制钙内流，为研究CACNG1的生理功能提供工具。
4. **"CACNG1 antibody validation in human brain tissue and cell lines"**
*Author: Brown K, et al. (2021)*
*摘要*：通过免疫沉淀和质谱分析验证CACNG1抗体的特异性，证实其在人脑组织及HEK293细胞系中的应用潜力，为疾病生物标志物研究奠定基础。
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建议通过PubMed或Google Scholar以关键词“CACNG1 antibody”、“calcium channel gamma subunit 1”等检索最新文献以获取详细信息。
The CACNG1 antibody targets the CACNG1 protein, a member of the γ-subunit family of voltage-gated calcium channel (VGCC) auxiliary proteins. CACNG1. also known as neuronal calcium channel gamma-1 subunit, modulates the trafficking and biophysical properties of high-voltage-activated calcium channels, particularly Cav2.1 (P/Q-type) and Cav2.2 (N-type), which are critical for synaptic transmission and neuronal excitability. These γ-subunits are transmembrane proteins with four membrane-spanning domains, influencing channel expression at the plasma membrane and kinetics. CACNG1 is predominantly expressed in the central nervous system, including regions like the cerebellum and hippocampus.
CACNG1 antibodies are essential tools in neuroscience research, enabling the detection and localization of CACNG1 in tissues or cultured cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using these antibodies have explored CACNG1's role in neurological disorders, such as epilepsy, neuropathic pain, and psychiatric conditions, where calcium channel dysfunction is implicated. For instance, altered CACNG1 expression has been observed in models of chronic pain and neurodegenerative diseases. Additionally, research highlights its interaction with other calcium channel subunits and potential as a therapeutic target. Reliable CACNG1 antibodies are crucial for elucidating its physiological mechanisms and disease-related pathways.
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