| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | dj747l4.c1.2; flj34085; rp4-747l4.1; sft2 domain containing 2; sft2b |
| Entrez GeneID | 375035; |
| WB Predicted band size | 18kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human SFT2B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SFT2B抗体的虚构参考文献示例(实际文献需根据具体研究验证)：
1. **文献名称**：*The role of Sft2p in yeast vesicle trafficking: antibody production and localization studies*
**作者**：Smith J, et al.
**摘要**：本研究开发了针对酵母Sft2蛋白的多克隆抗体，通过免疫荧光和Western blot分析，揭示了Sft2在内体-高尔基体逆向囊泡运输中的定位及功能。
2. **文献名称**：*Characterization of SFT2B in mammalian cells: implications for endosomal sorting*
**作者**：Lee H, et al.
**摘要**：利用特异性单克隆抗体，研究发现哺乳动物SFT2B蛋白与ESCRT复合物相互作用，调控内体分选及溶酶体降解途径。
3. **文献名称**：*SFT2B antibody disrupts synaptic vesicle recycling in neurons*
**作者**：Gomez M, et al.
**摘要**：通过抗SFT2B抗体的功能阻断实验，证实该蛋白在神经元突触小泡回收中的关键作用，影响神经递质释放效率。
4. **文献名称**：*Development of a plant SFT2B homolog antibody for membrane trafficking studies*
**作者**：Chen L, et al.
**摘要**：报道拟南芥SFT2B同源蛋白抗体的开发，应用于植物细胞内膜运输机制研究，揭示其在液泡形成中的调控功能。
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**注意**：以上文献为示例性质，实际引用需核实真实研究。建议通过学术数据库(如PubMed、Web of Science)以“SFT2B antibody”或“Sft2B function”为关键词检索最新文献。
The SFT2B antibody targets the Sphingosine-1-phosphate (S1P) transporter 2B, also known as SPNS2. a transmembrane protein critical for regulating S1P signaling. S1P is a bioactive lipid mediator involved in immune cell trafficking, vascular development, and inflammation. SPNS2 specifically exports S1P from intracellular compartments to the extracellular milieu, enabling its interaction with cell-surface receptors (S1PR1-5) to initiate downstream signaling. Dysregulation of SPNS2 is linked to pathologies such as cancer metastasis, autoimmune disorders, and cardiovascular diseases.
The SFT2B antibody is widely used in research to detect and quantify SPNS2 expression in tissues or cell lines. It facilitates studies on S1P transport mechanisms, immune modulation, and angiogenesis. Common applications include Western blotting, immunohistochemistry, and flow cytometry, often validated via knockout controls to ensure specificity.
Developed in host species like rabbits or mice, this tool has advanced understanding of SPNS2’s role in lymphocyte egress from lymphoid organs, endothelial barrier integrity, and tumor microenvironment regulation. Commercial availability and reliability make it essential for exploring therapeutic strategies targeting S1P pathways. Research using the SFT2B antibody continues to uncover its potential in treating inflammatory diseases, cancer, and metabolic syndromes.
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