Rabbit Polyclonal ATP6V1C2 Antibody

The ATP6V1C2 antibody is a research tool targeting the ATP6V1C2 protein, a subunit of the vacuolar-type H+-ATPase (V-ATPase) complex. V-ATPases are evolutionarily conserved proton pumps that acidify intracellular compartments (e.g., lysosomes, endosomes) and regulate extracellular pH in certain tissues. The ATP6V1C2 subunit, part of the V1 domain, facilitates ATP hydrolysis and participates in assembly/regulation of the complex. It is one of two isoforms (C1 and C2) encoded by distinct genes, with C2 showing tissue-specific expression in organs like the kidney, liver, and reproductive tissues. Dysregulation of ATP6V1C2 has been implicated in pathological processes, including cancer progression, where its overexpression correlates with metastasis, drug resistance, and poor prognosis in breast, prostate, and ovarian cancers. Antibodies against ATP6V1C2 are used to study its expression patterns, subcellular localization, and functional roles via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These tools help elucidate its contribution to pH-dependent processes such as protein degradation, membrane trafficking, and bone resorption. Recent studies also explore ATP6V1C2 as a potential therapeutic target, particularly in cancers reliant on V-ATPase activity for survival. Validation of antibody specificity through knockout controls or siRNA knockdown is critical due to structural homology between C1 and C2 isoforms.