关键信息
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基因名
DCLRE1A
- 应用
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别名
DCLRE1A；KIAA0086；SNM1；SNM1A；DNA cross-link repair 1A Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6PJP8
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表达区间
690-1040aa
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氨基酸序列
SSNVGGSRKKTCPFYKKIPGTGFTVDAFQYGVVEGCTAYFLTHFHSDHYAGLSKHFTFPVYCSEITGNLLKNKLHVQEQYIHPLPLDTECIVNGVKVVLLDANHCPGAVMILFYLPNGTVILHTGDFRADPSMERSLLADQKVHMLYLDTTYCSPEYTFPSQQEVIRFAINTAFEAVTLNPHALVVCGTYSIGKEKVFLAIADVLGSKVGMSQEKYKTLQCLNIPEINSLITTDMCSSLVHLLPMMQINFKGLQSHLKKCGGKYNQILAFRPTGWTHSNKFTRIADVIPQTKGNISIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGTWKSRSTMEKYFREWKLEAGY
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分子量
4.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
DCLRE1A, also known as DNA cross-link repair 1A, is a gene that encodes a protein involved in critical DNA repair processes, particularly in the repair of DNA interstrand cross-links. Mutations in this gene are associated with various genetic disorders, including Fanconi anemia, which leads to increased sensitivity to DNA cross-linking agents and exhibits features of bone marrow failure and predisposition to cancer. Research on DCLRE1A recombinant protein focuses on its role in maintaining genomic stability by facilitating the repair of damaged DNA. Understanding the function and mechanism of DCLRE1A can provide insights into the molecular pathways underlying DNA repair and the etiology of related diseases. Moreover, recombinant DCLRE1A can be utilized in biochemical assays and therapeutic applications, allowing for the exploration of potential interventions in DNA repair pathways. By elucidating the function of this protein, researchers aim to develop targeted therapies for conditions associated with defective DNA repair mechanisms, thus enhancing treatment strategies for diseases linked to genomic instability. Overall, the study of DCLRE1A recombinant protein is essential for advancing our understanding of DNA repair processes and their implications in human health.
