Rabbit Polyclonal THOC5 Antibody

The THOC5 antibody is a crucial tool in studying the THO complex, a conserved multiprotein assembly involved in mRNA processing and export from the nucleus to the cytoplasm. THOC5 (THO Complex subunit 5), also known as TASOC1 or CGI-66. is a specific component of the mammalian THO complex, which plays roles in transcription elongation, mRNA splicing, and nuclear export. Research highlights its importance in maintaining genome stability, regulating stem cell self-renewal, and modulating immune responses. Dysregulation of THOC5 has been linked to cancers, viral infections, and autoimmune diseases, making it a target for mechanistic and therapeutic studies. The THOC5 antibody enables detection and quantification of THOC5 protein levels in various experimental setups, including Western blotting, immunofluorescence, and immunoprecipitation. It helps investigate THOC5's interactions with other THO subunits, its role in mRNA export pathways, and its impact on cellular processes like proliferation and apoptosis. Commercial THOC5 antibodies are typically raised against specific epitopes, requiring validation for specificity and cross-reactivity. Studies using this antibody have advanced understanding of how THOC5 contributes to both normal cellular functions and disease pathologies, particularly in contexts involving oxidative stress or viral subversion of host mRNA machinery.