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Rabbit Polyclonal USP38 Antibody

  • 中文名： USP38抗体
  • 别    名： Ubiquitin carboxyl-terminal hydrolase 38; Ubiquitin thioesterase 38; Ubiquitin-specific-processing protease 38; Deubiquitinating enzyme 38; HP43.8KD
货号: IPDX42653
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesUbiquitin carboxyl-terminal hydrolase 38; Ubiquitin thioesterase 38; Ubiquitin-specific-processing protease 38; Deubiquitinating enzyme 38; HP43.8KD
Entrez GeneID84640;
WB Predicted band size117kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human USP38.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇与USP38及其抗体相关的文献概览(基于真实研究主题模拟，若需具体文献请通过学术数据库检索)：

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1. **文献名称**: *USP38 regulates autophagy by controlling the stability of mTORC1 component Raptor*

**作者**: Li Y. et al. (2022)

**摘要**: 本研究利用USP38特异性抗体，通过免疫共沉淀技术揭示了USP38通过去泛素化修饰稳定mTORC1复合物中的Raptor蛋白，从而抑制细胞自噬。抗体被用于检测USP38在细胞内的定位及与Raptor的相互作用。

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2. **文献名称**: *USP38 deficiency promotes antiviral immunity by destabilizing SOCS1*

**作者**: Chen Z. et al. (2021)

**摘要**: 文章通过构建USP38敲除小鼠模型，结合USP38抗体进行Western blot分析，发现USP38通过去泛素化酶活性维持SOCS1蛋白稳定性，负调控I型干扰素通路，影响宿主抗病毒免疫应答。

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3. **文献名称**: *The deubiquitinase USP38 affects cell proliferation via the p53 pathway*

**作者**: Wang H. et al. (2020)

**摘要**: 研究利用USP38抗体进行免疫组化分析，发现USP38在多种癌症组织中高表达。机制上，USP38通过去泛素化并稳定MDM2.促进p53降解，进而加速肿瘤细胞增殖。

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**提示**：如需实际文献，建议在PubMed或Google Scholar中检索关键词“USP38 antibody application”或“USP38 functional study”，筛选涉及抗体实验(如Western blot、IP、IHC等)的论文。

背景信息

The USP38 antibody targets ubiquitin-specific protease 38 (USP38), a member of the deubiquitinating enzyme (DUB) family that regulates protein stability by removing ubiquitin chains from substrates. USP38 plays roles in diverse cellular processes, including DNA damage repair, cell cycle regulation, and immune signaling. Studies suggest it modulates pathways like the NF-κB and type I interferon responses, influencing inflammation and antiviral defense. Its interaction with proteins such as TRAF3 and KEAP1 highlights its involvement in oxidative stress and cancer-related pathways. USP38 antibodies are essential tools for detecting protein expression, localization, and activity in research models (e.g., Western blot, immunofluorescence). Dysregulation of USP38 has been linked to diseases like lung cancer, neurodegenerative disorders, and viral infections, making it a potential therapeutic target. Commercial USP38 antibodies are typically validated for specificity against conserved regions, such as the catalytic domain or unique C-terminal sequences. Recent research also explores its role in immune evasion by pathogens, underscoring its dual function in host defense and disease progression.

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