| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; LYP1 |
| Entrez GeneID | 26191; |
| WB Predicted band size | 92kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from Internal of human PTPN22. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PTPN22抗体的3篇参考文献，简要概括如下：
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1. **文献名称**：*PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis*
**作者**：Bottini N, et al.
**摘要**：该研究探讨了PTPN22基因多态性(如R620W)与类风湿性关节炎(RA)和系统性红斑狼疮(SLE)的关联，发现其变异显著增加抗瓜氨酸化蛋白抗体(ACPA)阳性RA的风险，提示PTPN22在自身抗体产生中的调控作用。
2. **文献名称**：*A missense single-nucleotide polymorphism in the PTPN22 gene associates with anti-cyclic citrullinated peptide antibody-positive rheumatoid arthritis*
**作者**：Kyogoku C, et al.
**摘要**：研究证实PTPN22的R620W突变与ACPA阳性RA亚型密切相关，但对ACPA阴性RA无显著影响，表明该基因变异可能通过干扰T细胞信号通路促进自身抗体生成。
3. **文献名称**：*PTPN22 C1858T polymorphism and anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus*
**作者**：Stolp J, et al.
**摘要**：分析了PTPN22变异与系统性红斑狼疮(SLE)患者中抗双链DNA(dsDNA)抗体的关联，发现该突变与更高水平的自身抗体相关，提示其在SLE病理中的潜在作用。
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以上文献聚焦于PTPN22基因变异如何通过影响免疫调节通路，促进特定自身抗体(如ACPA、抗dsDNA抗体)的产生，进而参与RA、SLE等疾病的发病机制。
The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes lymphoid tyrosine phosphatase (LYP), a key regulator of immune cell signaling. Primarily expressed in hematopoietic cells, LYP modulates T-cell receptor (TCR) signaling by dephosphorylating activating kinases like Lck and Fyn, thereby acting as a negative regulator of T-cell activation. This regulation is critical for maintaining immune tolerance and preventing autoimmunity.
A single nucleotide polymorphism (SNP), C1858T (rs2476601), in the PTPN22 gene is strongly associated with multiple autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, and systemic lupus erythematosus. This variant results in an arginine-to-tryptophan substitution (R620W) that disrupts LYP's interaction with molecular partners like Csk, impairing its ability to suppress TCR signaling. Consequently, altered T-cell activation thresholds may promote autoreactive lymphocyte survival and autoimmune responses.
PTPN22 antibodies, often detected in autoimmune conditions, target the LYP protein. While their clinical utility remains under investigation, these antibodies may serve as biomarkers for disease progression or subtypes. Research suggests they could interfere with normal phosphatase activity, exacerbating signaling dysregulation. However, the exact pathogenic role of PTPN22 antibodies is less characterized compared to genetic variants. Current studies focus on elucidating their diagnostic/prognostic value and potential therapeutic targeting. Detection methods include ELISA and immunoblotting, though standardization is needed for clinical application.
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