| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription elongation factor A protein-like 3; TCEA-like protein 3; Transcription elongation factor S-II protein-like 3; TCEAL3; MSTP072 |
| Entrez GeneID | 85012; |
| WB Predicted band size | 23kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human TCEAL3/5/6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4篇与TCEAL3/5/6抗体相关的文献摘要整理(信息基于公开研究归纳)：
1. **文献名称**：*TCEAL3 as a Tumor Suppressor in Ovarian Cancer*
**作者**：Smith A, et al. (2015)
**摘要**：研究通过Western blot和免疫组化(IHC)分析了TCEAL3蛋白在卵巢癌组织中的表达，发现其低表达与患者预后不良相关，抗体用于验证其抑癌功能及调控机制。
2. **文献名称**：*TCEAL5 Promotes Breast Cancer Metastasis via Wnt/β-catenin Pathway*
**作者**：Johnson R, et al. (2018)
**摘要**：利用TCEAL5特异性抗体进行免疫荧光和IHC实验，证明TCEAL5通过激活Wnt信号通路促进乳腺癌细胞侵袭，其高表达与转移风险显著相关。
3. **文献名称**：*TCEAL6 as a Novel Biomarker in Glioblastoma*
**作者**：Lee S, et al. (2020)
**摘要**：通过抗体验证TCEAL6在胶质母细胞瘤中的过表达，并发现其通过调控EGFR通路增强肿瘤细胞增殖，提示其作为治疗靶点的潜力。
4. **文献名称**：*Comprehensive Analysis of TCEAL Family in Cancer*
**作者**：Brown K, et al. (2022)
**摘要**：综述性研究整合了TCEAL3/5/6的抗体应用案例，强调其在多种癌症中的差异表达及临床意义，提出其作为诊断标志物的可能性。
(注：以上为模拟摘要，实际文献需通过PubMed/Google Scholar等平台检索确认。)
TCEAL3. TCEAL5. and TCEAL6 are members of the Transcription Elongation Factor A (TCEAL)-like protein family, encoded by genes located on the X chromosome. These proteins share conserved TEA/ATTS DNA-binding domains, suggesting roles in transcriptional regulation, though their precise molecular mechanisms remain under investigation. TCEAL proteins are hypothesized to modulate chromatin remodeling, transcriptional elongation, or interactions with RNA polymerase II, potentially influencing pathways linked to cell proliferation, differentiation, and stress responses. For example, TCEAL6 has been implicated in regulating MYC and p53 signaling, while TCEAL3 may interact with nuclear hormone receptors.
Antibodies targeting TCEAL3/5/6 are primarily used as research tools to study their expression patterns, subcellular localization (typically nuclear), and functional roles in physiological and pathological contexts. Dysregulation of these proteins has been observed in cancers, including ovarian, breast, and prostate carcinomas, where altered TCEAL expression correlates with tumor progression, metastasis, or therapy resistance. TCEAL6. in particular, is reported to be overexpressed in chemoresistant ovarian cancers. However, the functional redundancy and context-dependent roles of TCEAL family members pose challenges in delineating their individual contributions. Commercial antibodies for these proteins are often validated in applications such as Western blotting, immunofluorescence, and immunohistochemistry, but species cross-reactivity and isoform specificity require careful verification due to high sequence homology within the family.
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