Cat: PA1000-2049

Recombinant Human MX2 Protein,His

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关键信息

  • 基因名

    MX2

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    MX2;Interferon-induced GTP-binding Protein Mx2

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P20592

  • 表达区间

    626-715aa

  • 氨基酸序列

    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSIGIH LNAYFLETSK RLANQIPFII QYFMLRENGD SLQKAMMQIL QEKNRYSWLL QEQSETATKR RILKERIYRL TQARHALCQF SSKEIH

  • 分子量

    15 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

MX2, a member of the MX (myxovirus resistance) family of proteins, plays a crucial role in the innate immune response against viral infections. Originally identified for its antiviral properties against various RNA viruses, including influenza and HIV, research has increasingly focused on MX2's function in cellular immunity and its potential therapeutic applications. The protein is induced by interferons, which are crucial signaling molecules in the immune response, highlighting its importance in antiviral defense mechanisms. Recent studies have demonstrated that MX2 can inhibit HIV-1 replication by interfering with the viral life cycle, particularly during the early stages of infection. This discovery has propelled interest in MX2 as a potential target for antiviral therapies, especially in the context of emerging viral pathogens. Additionally, structural and functional analyses of MX2 have provided insights into its mechanism of action and the molecular pathways involved in its antiviral effects. Consequently, understanding MX2's role in the immune system may lead to novel strategies for enhancing antiviral responses and developing new treatments for viral infections. Ongoing research aims to elucidate the full scope of MX2's functionality, its interactions with other cellular proteins, and its regulation, ultimately contributing to the advancement of immunology and virology.

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