Rabbit Polyclonal CCT6A Antibody

The CCT6A antibody targets the CCT6A (Chaperonin Containing TCP1 Subunit 6A) protein, a critical component of the chaperonin-containing TCP1 (CCT) complex. This evolutionarily conserved complex, also known as TRiC, facilitates ATP-dependent folding of nascent polypeptides, particularly cytoskeletal proteins like actin and tubulin. CCT6A, one of eight paralogous subunits forming the double-ring CCT structure, plays a specialized role in substrate recognition and binding. Dysregulation of CCT6A has been implicated in various cancers, where its overexpression correlates with tumor progression, metastasis, and poor prognosis, potentially through interactions with oncogenic signaling pathways. In neurodegenerative diseases, altered CCT6A expression may contribute to protein aggregation pathologies. Researchers utilize CCT6A antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and functional roles in protein homeostasis, cell cycle regulation, and stress responses. Recent studies also explore its potential as a therapeutic target or biomarker in precision oncology. Proper validation of CCT6A antibodies remains essential due to high homology among CCT subunits.