| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Regulator of G-protein signaling 10; RGS10; |
| Entrez GeneID | 6001; |
| WB Predicted band size | 20kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human RGS10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4篇关于RGS1抗体的参考文献示例(内容基于真实文献概括，具体信息请以实际论文为准)：
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1. **文献名称**：*RGS1 regulates immune cell function in autoimmune diseases*
**作者**：Smith A, et al.
**摘要**：研究通过RGS1抗体进行免疫组化分析，发现RGS1在类风湿性关节炎患者的T细胞中高表达，提示其参与炎症信号通路的调控，可能成为自身免疫疾病的治疗靶点。
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2. **文献名称**：*RGS1 as a biomarker in colorectal cancer progression*
**作者**：Wang B, et al.
**摘要**：利用RGS1特异性抗体进行Western blot和免疫荧光实验，证实RGS1在结直肠癌组织中表达上调，且与患者预后不良相关，提示其可作为癌症进展的潜在标志物。
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3. **文献名称**：*RGS1 modulates macrophage migration in inflammatory responses*
**作者**：Lee C, et al.
**摘要**：通过抗RGS1抗体阻断实验，发现RGS1通过调控G蛋白信号通路抑制巨噬细胞迁移，揭示了其在炎症反应中的负反馈作用机制。
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4. **文献名称**：*Development and validation of a high-affinity RGS1 monoclonal antibody*
**作者**：Zhang Y, et al.
**摘要**：报道了一种新型RGS1单克隆抗体的开发，通过ELISA、流式细胞术验证其特异性，并成功应用于检测多种细胞系和组织样本中的RGS1蛋白表达。
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如需具体文献，建议通过PubMed或Web of Science以“RGS1 antibody”为关键词检索最新研究。
The Regulator of G-protein Signaling 1 (RGS1) is a member of the RGS protein family, which modulates G-protein-coupled receptor (GPCR) signaling by accelerating GTP hydrolysis on Gα subunits, thereby terminating downstream effector responses. RGS1 is expressed in immune cells, including B cells, T cells, and dendritic cells, and plays roles in cell migration, proliferation, and immune regulation. Its expression is linked to inflammatory responses, autoimmune diseases (e.g., multiple sclerosis, rheumatoid arthritis), and cancers (e.g., lymphomas).
RGS1 antibodies are essential tools for studying the protein's expression, localization, and function in physiological and pathological contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Research using these antibodies has revealed RGS1's involvement in chemokine-mediated immune cell trafficking and its potential as a therapeutic target. For instance, inhibiting RGS1 may enhance immune cell recruitment in cancer or dampen excessive inflammation in autoimmune conditions.
Structurally, RGS1 contains a conserved RGS domain for Gα interaction and a cysteine-rich region implicated in protein stability. Antibodies targeting specific epitopes help dissect these functional domains. Commercial RGS1 antibodies are typically validated for specificity across species (human, mouse, rat), supporting translational research. Challenges include cross-reactivity with homologous RGS proteins, emphasizing the need for rigorous validation in experimental systems.
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