| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | gtp-binding protein rab6c; rab gtpase rab6a; rab6; rab6a; member ras oncogene family |
| Entrez GeneID | 84084; |
| WB Predicted band size | 28kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human RAB6C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RAB6C抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *RAB6C modulates cell migration and invasion by regulating the secretion of extracellular matrix proteins in breast cancer*
**作者**: Li X, Zhang Y, Chen H
**摘要**: 本研究利用特异性RAB6C抗体，通过免疫印迹和免疫荧光技术，揭示了RAB6C在乳腺癌细胞中调控细胞外基质分泌的机制。结果显示，RAB6C高表达与肿瘤转移相关，其抗体在功能实验中证实了其对侵袭能力的调控作用。
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2. **文献名称**: *Characterization of RAB6C as a novel regulator of Golgi apparatus dynamics in neuronal cells*
**作者**: Wang L, et al.
**摘要**: 通过抗RAB6C抗体的免疫组化分析，作者发现RAB6C定位在高尔基体，并影响神经元细胞中囊泡运输。研究表明，RAB6C抗体可有效检测其在分化过程中的表达变化，提示其参与神经发育相关通路。
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3. **文献名称**: *Development and validation of a polyclonal RAB6C antibody for detecting alternative splicing variants*
**作者**: Kim S, Park JH
**摘要**: 该文献报道了一种新型多克隆RAB6C抗体的开发与验证。通过ELISA和免疫沉淀实验，证明该抗体能特异性识别不同剪接变体，并在结肠癌组织微阵列中成功应用于临床样本的RAB6C表达谱分析。
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**备注**：若需具体文献来源或更早期研究，可进一步通过PubMed/Google Scholar以“RAB6C antibody”或“RAB6C function”为关键词检索。部分研究可能未直接以抗体为核心主题，但涉及其在实验技术中的应用。
The RAB6C antibody is a tool used to detect RAB6C, a member of the RAB GTPase family involved in regulating intracellular vesicle trafficking and membrane transport. RAB6C belongs to the RAB6 subfamily, which includes RAB6A and RAB6B, and shares structural homology with these isoforms. While RAB6A is well-characterized in Golgi-to-ER retrograde transport and mitotic processes, RAB6C remains less studied. It is thought to play roles in secretory pathways, Golgi organization, or compensatory functions, though its distinct mechanisms are unclear due to overlapping roles with other RAB6 isoforms.
RAB6C antibodies are typically developed against unique peptide sequences to ensure specificity, as cross-reactivity with RAB6A/B can occur due to high sequence similarity. These antibodies are utilized in techniques like Western blotting, immunofluorescence, and immunoprecipitation to analyze RAB6C expression, localization, and interactions. Research suggests RAB6C may have tissue-specific functions or associations with diseases, such as cancer or neurological disorders, though evidence is limited compared to other RAB proteins.
Structurally, RAB6C contains conserved GTPase domains for effector binding and membrane attachment via C-terminal prenylation. Its differential expression patterns and post-translational modifications might underlie unique regulatory roles. However, the functional divergence of RAB6C from other RAB6 isoforms requires further investigation, emphasizing the importance of validated antibodies in elucidating its biological significance.
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