Rabbit Polyclonal ABCC13 Antibody

The ABCC13 antibody is designed to target the ATP-binding cassette subfamily C member 13 (ABCC13), a protein encoded by the ABCC13 gene in humans. ABCC13 belongs to the ABC transporter superfamily, which plays critical roles in cellular transport processes, including drug resistance, lipid trafficking, and detoxification. However, ABCC13 is considered a pseudogene in many human populations due to premature stop codons and frameshift mutations, leading to a truncated, non-functional protein. Despite this, low-level expression of ABCC13 transcripts has been detected in tissues like the liver, testes, and placenta, suggesting potential residual or context-specific functionality. Research on ABCC13 antibodies focuses on elucidating its expression patterns, evolutionary conservation, and possible roles in physiological or pathological conditions. These antibodies are utilized in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study protein localization and expression. Investigations also explore ABCC13's hypothetical involvement in diseases like cancer or metabolic disorders, drawing parallels to functional ABC transporters linked to chemotherapy resistance. However, its pseudogene status complicates research, requiring careful validation of antibody specificity to avoid cross-reactivity with other ABCC family members. Current studies aim to clarify whether ABCC13 retains any biological relevance or serves as an evolutionary relic in humans.