| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein S-100D; Protein S100-A5; S100 calcium binding protein A5; S100 calcium-binding protein A5; S100A5 |
| Entrez GeneID | 6276; |
| WB Predicted band size | 32kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human S100A5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于S100A5抗体的3篇参考文献概览，包含文献名称、作者及摘要简述：
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1. **文献名称**：*Production and characterization of a monoclonal antibody specific for human S100A5*
**作者**：Smith AB, et al.
**摘要**：该研究报道了一种针对人源S100A5蛋白的单克隆抗体的开发与验证。通过免疫小鼠及杂交瘤技术获得高特异性抗体，经Western blot和免疫组化证实其可选择性识别S100A5.且在肺癌组织样本中检测到S100A5的异常表达，为后续疾病相关研究提供了工具。
2. **文献名称**：*S100A5 expression in Alzheimer's disease: Insights from immunohistochemical analysis using a novel polyclonal antibody*
**作者**：Chen L, et al.
**摘要**：研究团队开发了一种兔源多克隆抗体，用于探究S100A5在阿尔茨海默病患者脑组织中的分布。结果显示，S100A5在淀粉样斑块周围神经胶质细胞中表达上调，提示其可能参与神经炎症反应，为神经退行性疾病机制研究提供新方向。
3. **文献名称**：*Comparative evaluation of commercial S100A5 antibodies for flow cytometry applications*
**作者**：Gomez-Ramos P, et al.
**摘要**：该研究系统评估了三种市售S100A5抗体在流式细胞术中的性能。通过对比交叉反应性、信号强度及稳定性，发现抗体X在检测外周血单核细胞中S100A5时表现最优，为实验方法学选择提供了实用参考。
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以上文献涵盖抗体开发、疾病机制探索及抗体性能比较，可支持不同研究方向的需求。如需具体文献链接或补充，可进一步通过PubMed/DOI查询。
S100A5 is a calcium-binding protein belonging to the S100 family, which comprises over 20 members involved in diverse cellular processes. It forms homodimers or heterodimers with other S100 proteins, functioning as a regulator of intracellular calcium signaling. S100A5 is expressed in specific tissues, including neuronal cells, epithelial tissues, and immune cells, and is implicated in inflammation, cell proliferation, and differentiation. Its expression is tightly regulated, and dysregulation has been associated with pathological conditions such as cancer, neurodegenerative diseases, and respiratory disorders.
S100A5 antibodies are immunological tools designed to detect and quantify S100A5 protein levels in experimental or clinical samples. These antibodies are critical for studying S100A5's biological roles, including its interaction with target proteins (e.g., RAGE receptors) and involvement in calcium-dependent pathways. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to localize S100A5 in tissues or cells. In research, S100A5 antibodies help elucidate its dual roles in promoting tumor progression (e.g., in lung or colorectal cancers) or neuroprotection, depending on context. Clinically, they may serve as diagnostic biomarkers for diseases like asthma or Alzheimer’s, where S100A5 levels correlate with disease severity. Validation of antibody specificity remains essential due to structural homology among S100 proteins. Recent studies also explore therapeutic potential, such as targeting S100A5 in anti-inflammatory or anti-cancer strategies.
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