| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IGSF11 |
| Uniprot No | Q5DX21 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 22-245aa |
| 氨基酸序列 | SLEVSESPG SIQVARGQPA VLPCTFTTSA ALINLNVIWM VTPLSNANQP EQVILYQGGQ MFDGAPRFHG RVGFTGTMPA TNVSIFINNT QLSDTGTYQC LVNNLPDIGG RNIGVTGLTV LVPPSAPHCQ IQGSQDIGSD VILLCSSEEG IPRPTYLWEK LDNTLKLPPT ATQDQVQGTV TIRNISALSS GLYQCVASNA IGTSTCLLDL QVISPQPRNI GLIAG |
| 预测分子量 | 52 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IGSF11重组蛋白的模拟参考文献(非真实文献，仅供示例参考)：
1. **文献名称**：*IGSF11重组蛋白在肿瘤免疫逃逸中的功能研究*
**作者**：Zhang L, et al.
**摘要**：本研究通过重组表达人源IGSF11蛋白，发现其能够通过抑制T细胞活化信号通路(如PD-1/PD-L1)促进肿瘤细胞免疫逃逸，提示其可能作为肿瘤免疫治疗的潜在靶点。
2. **文献名称**：*重组IGSF11蛋白的晶体结构及其与配体相互作用的分析*
**作者**：Wang Y, et al.
**摘要**：首次解析了IGSF11重组蛋白的晶体结构，揭示了其免疫球蛋白样结构域的关键功能区域，并发现其与神经轴突导向分子Netrin-1存在特异性结合，可能参与神经发育调控。
3. **文献名称**：*IGSF11重组蛋白在肝细胞癌中的异常表达及临床意义*
**作者**：Chen H, et al.
**摘要**：利用重组IGSF11蛋白制备抗体，发现其在肝癌组织中高表达，且与患者预后不良显著相关，机制可能涉及Wnt/β-catenin信号通路的异常激活。
4. **文献名称**：*基于重组IGSF11蛋白的自身免疫性疾病诊断标志物开发*
**作者**：Smith J, et al.
**摘要**：通过ELISA检测发现，类风湿关节炎患者血清中抗IGSF11抗体水平显著升高，提示重组IGSF11蛋白可作为自身免疫性疾病的新型诊断标志物。
(注：以上文献为示例性内容，实际文献需通过PubMed、Google Scholar等平台检索。)
**Background of IGSF11 Recombinant Protein**
IGSF11 (Immunoglobulin Superfamily Member 11), also known as BT-IgSF or VSIG3. is a transmembrane protein belonging to the immunoglobulin superfamily (IgSF). It is characterized by extracellular immunoglobulin (Ig) domains that mediate cell-cell interactions and intracellular signaling. IGSF11 is evolutionarily conserved and expressed in various tissues, including the brain, immune system, and reproductive organs. Its structural features suggest roles in adhesion, receptor-ligand interactions, and immune regulation.
Functionally, IGSF11 has been implicated in modulating synaptic plasticity in neurons and regulating spermatogenesis in the testes. Recent studies highlight its emerging role in cancer biology, where it may influence tumor progression by interacting with immune checkpoints or promoting metastasis. For instance, IGSF11 overexpression in certain cancers correlates with immune evasion and poor prognosis, potentially through interactions with inhibitory receptors on T cells or by disrupting intercellular adhesion.
Recombinant IGSF11 protein is engineered using expression systems (e.g., mammalian cells) to produce soluble, bioactive forms of the protein for research. This tool enables the study of IGSF11’s binding partners, signaling pathways, and therapeutic potential. Its applications include *in vitro* assays to map protein interactions, functional studies in immune modulation, and drug discovery targeting cancers or neurological disorders.
Interest in IGSF11 has grown due to its dual roles in physiological processes and disease, positioning it as a potential biomarker or therapeutic target. Further research is needed to fully elucidate its mechanisms and translational relevance.
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