Rabbit Polyclonal KCNS2 Antibody

The KCNS2 antibody is a tool used to detect the KCNS2 protein, a member of the potassium voltage-gated channel subfamily S (Kv9). Encoded by the *KCNS2* gene, this protein forms delayed-rectifier potassium channels, primarily in the nervous system. These channels regulate neuronal excitability by controlling potassium efflux during action potential repolarization, influencing signal transmission and cellular homeostasis. KCNS2 does not form functional channels alone but modulates the activity of other Kvα subunits (e.g., KCNB1), altering kinetics and voltage dependence. Dysregulation of KCNS2 is linked to neurological disorders, including epilepsy, chronic pain, and neurodegeneration. Antibodies targeting KCNS2 enable researchers to study its expression, localization, and interaction partners in tissues or cell models. They are critical for techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding investigations into its role in disease mechanisms or neuronal plasticity. Commercial KCNS2 antibodies are typically validated for specificity via knockout controls or siRNA knockdown. However, variability in antibody performance (e.g., cross-reactivity) requires careful optimization. Research on KCNS2 remains pivotal for understanding potassium channel biology and developing targeted therapies for neurological conditions.