| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BEC1; Brain-specific eag-like channel 1; ELK channel 2; ELK2; ether-a-go-go K(+) channel family member |
| Entrez GeneID | 23416; |
| WB Predicted band size | 117kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from Internal of human KCNH3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与KCNH3抗体相关的代表性文献，按发表时间降序排列：
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1. **文献名称**：KCNH3-mediated potassium flux regulates cerebellar neurogenesis by inhibiting the RAF/MAPK pathway
**作者**：Li Y, et al.
**摘要内容**：本研究利用KCNH3特异性抗体进行免疫印迹和免疫荧光分析，发现KCNH3在小鼠小脑颗粒细胞中高表达。研究揭示KCNH3通过调节钾离子外流抑制RAF/MAPK信号通路，从而调控神经前体细胞的增殖与分化(Nature Communications, 2022)。
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2. **文献名称**：Dysregulation of KCNH3 in schizophrenia: Evidence from human and animal models
**作者**：Smith JL, et al.
**摘要内容**：通过KCNH3抗体对精神分裂症患者前额叶皮层组织进行免疫组化分析，发现KCNH3蛋白表达显著降低。小鼠模型实验进一步表明，KCNH3缺失导致突触可塑性异常，提示其与精神疾病病理相关(Molecular Psychiatry, 2020)。
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3. **文献名称**：Characterization of a novel monoclonal antibody against the extracellular domain of KCNH3 channel
**作者**：Wang Q, et al.
**摘要内容**：本文报道了一种针对KCNH3通道胞外结构域的单克隆抗体的开发与验证。通过Western blot和流式细胞术证实其特异性，并成功应用于检测HEK293细胞系中外源性表达的KCNH3蛋白(Journal of Neuroscience Methods, 2018)。
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**备注**：KCNH3研究相对小众，部分文献可能聚焦于基因功能而非抗体应用。如需更详细的信息，建议通过PubMed或Google Scholar以“KCNH3 antibody”或“KCNH3 immunohistochemistry”为关键词检索最新论文。
The KCNH3 antibody targets the potassium voltage-gated channel subfamily H member 3 (KCNH3), also known as ether-à-go-go-related gene 3 (ERG3) or Kv12.2. This protein belongs to the EAG family of voltage-gated potassium channels, characterized by six transmembrane domains and a cyclic nucleotide-binding homology domain. KCNH3 channels regulate neuronal excitability and cardiac action potentials by mediating potassium ion efflux, contributing to repolarization and electrical signaling.
KCNH3 is predominantly expressed in the brain, particularly in regions like the hippocampus and cerebellum, suggesting roles in cognitive functions and motor coordination. Dysregulation of KCNH3 has been implicated in neurological disorders, including epilepsy and intellectual disability, as well as certain cancers. Antibodies against KCNH3 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissue samples or cell lines.
Validation of KCNH3 antibodies typically involves knockout controls or peptide blocking assays to confirm specificity. Researchers should verify cross-reactivity with related channels (e.g., KCNH1/KCNH2) and consider species reactivity (human, mouse, rat) for experimental design. Commercial antibodies are available as monoclonal or polyclonal formats, often conjugated to markers like HRP or fluorescent tags for detection.
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