| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Prostaglandin reductase 1; PRG-1; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; EC=1.3.1.74; 15-oxoprostaglandin 13-reductase |
| Entrez GeneID | 22949; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human PTGR1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PTGR1抗体的3篇参考文献示例(文献信息及摘要内容为示例性概括，实际引用需以真实文献为准)：
1. **"PTGR1 regulates lipid metabolism and prostate cancer progression via a novel signaling axis"**
*Authors: Zhang Y, et al.*
**摘要**：研究通过开发特异性PTGR1抗体，揭示了PTGR1在前列腺癌中通过调控脂质代谢促进肿瘤进展的机制，抗体被用于Western blot和免疫组化检测肿瘤组织中PTGR1蛋白表达水平。
2. **"Characterization of a monoclonal antibody against human PTGR1 for inflammatory disease studies"**
*Authors: Lee S, Kim JH.*
**摘要**：报道了一种新型抗人PTGR1单克隆抗体的制备与验证，该抗体能特异性识别天然和重组PTGR1蛋白，应用于炎症模型小鼠组织中PTGR1的免疫荧光定位及表达定量分析。
3. **"PTGR1 modulates oxidative stress in hepatocellular carcinoma: Insights from antibody-based proteomic profiling"**
*Authors: Wang X, et al.*
**摘要**：利用PTGR1抗体进行肝癌组织芯片的蛋白质组学分析，发现PTGR1高表达与氧化应激通路激活相关，提示其作为肝癌预后标志物的潜力。抗体验证通过siRNA敲低和ELISA交叉反应实验完成。
**注**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词(如“PTGR1 antibody”、“PTGR1 immunohistochemistry”)获取准确信息。
PTGR1 (Prostaglandin Reductase 1) is an enzyme encoded by the PTGR1 gene, belonging to the short-chain dehydrogenase/reductase (SDR) family. It catalyzes the reduction of conjugated double bonds in prostaglandins, particularly converting prostaglandin E2 (PGE2) to 15-keto-PGE2. thereby regulating inflammatory responses and lipid metabolism. PTGR1 is implicated in various physiological and pathological processes, including inflammation, oxidative stress, and cancer progression. Its expression is often dysregulated in tumors, such as hepatocellular carcinoma and colorectal cancer, where it may influence cell proliferation, apoptosis, and metastasis through interactions with signaling pathways like NF-κB and Wnt/β-catenin.
PTGR1 antibodies are essential tools for studying the protein's expression, localization, and function in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to quantify PTGR1 levels in tissues or cell lines, aiding in the exploration of its role in disease mechanisms. Commercially available PTGR1 antibodies are typically validated for specificity and sensitivity, often targeting conserved epitopes across human, mouse, and rat species. Research utilizing PTGR1 antibodies has highlighted its potential as a biomarker for cancer prognosis and as a therapeutic target, particularly in inflammation-related malignancies. Ongoing studies continue to unravel its complex regulatory networks in metabolic and oncogenic contexts.
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