| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein Hox-A11; Hox-1I; HOXA11; HOX1I; |
| Entrez GeneID | 3207; |
| WB Predicted band size | 28kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human HOXA11/D11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HOXA11/D11抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：
1. **文献名称**：*HOXA11 expression in endometriosis: Diagnostic and prognostic implications*
**作者**：Li, X., et al.
**摘要**：该研究通过免疫组化检测HOXA11蛋白在子宫内膜异位症组织中的表达，发现其显著高表达并与疾病严重程度相关，提示HOXA11抗体可作为潜在诊断工具。
2. **文献名称**：*HOXA11-AS1 promotes gastric cancer progression by sponging miR-200 family*
**作者**：Wang, Y., et al.
**摘要**：研究利用Western blot和免疫荧光技术，证实HOXA11-AS1通过调控HOXA11蛋白表达影响胃癌细胞侵袭性，HOXA11抗体用于验证其下游分子机制。
3. **文献名称**：*Developmental regulation of Hoxd11 in limb morphogenesis*
**作者**：Kmita, M., et al.
**摘要**：通过小鼠模型研究HOXD11在肢体发育中的作用，使用特异性抗体定位其蛋白表达模式，揭示其在前肢形成中的关键调控作用。
4. **文献名称**：*HOXA11 as a biomarker for ovarian cancer recurrence*
**作者**：Chen, L., et al.
**摘要**：研究采用ELISA和免疫组化分析HOXA11蛋白水平，发现其高表达与卵巢癌复发风险显著相关，支持其作为预后标志物的潜力。
(注：上述文献为示例，实际引用需根据具体研究调整。)
The HOXA11 and HOXD11 genes belong to the HOX family of homeobox transcription factors, which play critical roles in embryonic development, particularly in patterning the anterior-posterior axis and regulating organogenesis. HOXA11 is primarily associated with the development of the reproductive tract, limbs, and kidneys, while HOXD11 is involved in limb morphogenesis and axial skeleton formation. Both genes encode proteins containing a conserved DNA-binding homeodomain, enabling them to regulate downstream target genes by binding specific promoter regions.
Antibodies targeting HOXA11/D11 are widely used in research to investigate their expression patterns, functional roles, and dysregulation in diseases. HOXA11 antibodies, for instance, have been instrumental in studying uterine development and pathologies such as endometriosis or reproductive disorders. HOXD11 antibodies are often applied in limb development studies or cancer research, where aberrant HOX signaling is linked to tumor progression.
These antibodies are validated for techniques like immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF), aiding in cellular localization and protein quantification. Dysregulation of HOXA11/D11 has been observed in cancers (e.g., leukemia, ovarian cancer) and congenital malformations, making these antibodies valuable tools for both basic research and clinical diagnostics. Their specificity and reliability depend on epitope design and validation methods, which are critical for accurate interpretation of experimental results.
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