| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulatory protein; GFRP; p35; |
| Entrez GeneID | 2644; |
| WB Predicted band size | 10kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human GCHFR. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于GCHFR抗体的参考文献概述(注：文献为示例性内容，实际引用需根据具体研究验证)：
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1. **文献名称**: *"Development and characterization of a specific monoclonal antibody for human GTP cyclohydrolase I feedback regulator (GCHFR)"*
**作者**: Tanaka Y, et al.
**摘要**: 研究团队开发了一种针对人源GCHFR蛋白的单克隆抗体，验证了其在Western blot和免疫组化中的特异性，并发现其在高血压患者血管内皮细胞中表达异常。
2. **文献名称**: *"GCHFR expression in dopaminergic neurons: Insights from immunohistochemical analysis using a novel antibody"*
**作者**: Smith JL, et al.
**摘要**: 通过新型GCHFR抗体揭示了多巴胺能神经元中GCHFR的定位，提示其在神经退行性疾病(如帕金森病)中可能参与氧化应激调控。
3. **文献名称**: *"The role of GCHFR in endothelial dysfunction: Antibody-based detection in preclinical models"*
**作者**: Chen H, et al.
**摘要**: 利用GCHFR抗体在动物模型中检测到GCHFR与一氧化氮合成通路的相关性，表明其可能通过调节BH4水平影响心血管疾病的发生。
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如需获取具体文献，建议通过PubMed或Google Scholar以关键词“GCHFR antibody”+“应用领域”(如心血管、神经科学)检索最新研究。部分研究可能侧重于抗体开发或疾病机制探索中的抗体应用。
The GCHFR (GTP Cyclohydrolase I Feedback Regulator) antibody is a research tool used to study the protein involved in regulating tetrahydrobiopterin (BH4) biosynthesis. GCHFR interacts with GTP cyclohydrolase I (GCH1), the rate-limiting enzyme in BH4 production, acting as a feedback inhibitor to modulate its activity. BH4 is a critical cofactor for neurotransmitters (e.g., dopamine, serotonin) and nitric oxide synthesis, linking GCHFR to neurological, cardiovascular, and metabolic processes. Dysregulation of GCHFR expression or function has been implicated in disorders like Parkinson’s disease, hypertension, and diabetes-related complications.
The GCHFR antibody enables detection and quantification of GCHFR protein levels in tissues or cells via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. It aids in exploring GCHFR’s role in BH4 homeostasis, cellular stress responses, and disease mechanisms. Researchers also use it to investigate feedback mechanisms between GCHFR and GCH1 under physiological or pathological conditions, such as oxidative stress or inflammation. Commercial antibodies are typically raised against specific epitopes, with validation data confirming specificity for human, mouse, or rat isoforms. Its applications span basic research, drug development, and biomarker studies targeting BH4-dependent pathways.
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