| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | connexin 37; gap junction protein; alpha 4; 37kDa; |
| Entrez GeneID | 2701; |
| WB Predicted band size | 37kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from nal of human GJA4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GJA4抗体的3篇参考文献摘要示例(注：文献为虚拟示例，实际文献需根据具体数据库查询)：
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1. **文献名称**: *"Role of Connexin 37 (GJA4) in Placental Vascular Development and Preeclampsia"*
**作者**: Gabrielsen, A. et al.
**摘要**: 研究利用GJA4抗体通过免疫组化分析发现，子痫前期患者胎盘中GJA4蛋白表达显著降低，提示其可能通过调控胎盘血管重塑参与疾病发生。
2. **文献名称**: *"Antibody-based Detection of GJA4 in Murine Oocyte Development"*
**作者**: Simon, M. et al.
**摘要**: 通过Western blot和免疫荧光技术，验证了GJA4抗体在小鼠卵母细胞中的特异性，发现GJA4在卵母细胞间隙连接中动态表达，影响细胞间通讯与成熟。
3. **文献名称**: *"Connexin 37 (GJA4) as a Biomarker in Atherosclerotic Plaque Formation"*
**作者**: Haefliger, J.A. et al.
**摘要**: 研究使用GJA4抗体分析动脉粥样硬化模型，发现GJA4在病变血管内皮中异常高表达，可能通过调控炎症反应促进斑块形成。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“GJA4 antibody”或“Connexin 37 antibody”获取最新研究。
The GJA4 antibody targets the Gap Junction Alpha-4 protein (GJA4), also known as Connexin 37 (Cx37), a member of the connexin family that forms intercellular channels facilitating direct communication between cells. These channels enable the exchange of ions, metabolites, and signaling molecules, playing critical roles in tissue homeostasis and coordinated cellular activities. GJA4 is predominantly expressed in vascular endothelial cells, ovarian granulosa cells, and smooth muscle, where it regulates processes like vascular remodeling, follicular development, and immune response. Dysregulation of GJA4 has been implicated in pathologies such as atherosclerosis, reproductive disorders, and tumor angiogenesis.
The GJA4 antibody is a vital tool for studying the protein's expression, localization, and function in both physiological and disease contexts. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate GJA4's role in cell-cell communication, particularly in endothelial barrier integrity and ovarian follicle maturation. Recent research also explores its potential as a therapeutic target, given its involvement in tumor vasculature and inflammatory responses. Commercial GJA4 antibodies are typically validated for specificity and sensitivity across human, mouse, and rat models, supporting translational studies in cardiovascular biology, oncology, and reproductive health.
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