| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-interferon-inducible protein Ifi-16; Interferon-inducible myeloid differentiation transcriptional activator; IFI 16; |
| Entrez GeneID | 3428; |
| WB Predicted band size | 88kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human IFI16. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IFI16抗体的3篇代表性文献的简要概述(示例基于领域内常见研究方向，具体文献请根据实际需求检索确认)：
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1. **文献名称**: *"IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication"*
**作者**: Monroe KM 等
**摘要**: 该研究通过使用IFI16特异性抗体进行免疫沉淀和Western blot分析，揭示了IFI16在识别HIV-1复制过程中产生的DNA中间体并触发抗病毒免疫反应的作用，为HIV感染中的先天免疫机制提供了新见解。
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2. **文献名称**: *"The interferon-inducible protein IFI16 recognizes herpes simplex-1 by DNA structure to activate inflammasome signaling"*
**作者**: Kerur N 等
**摘要**: 研究利用IFI16抗体进行免疫荧光染色和功能抑制实验，证明IFI16通过识别HSV-1病毒DNA的二级结构，激活炎症小体并诱导IL-1β分泌，阐明了其在抗疱疹病毒免疫中的关键角色。
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3. **文献名称**: *"Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and inhibition of virus replication by IFI16"*
**作者**: Li T 等
**摘要**: 通过抗体介导的IFI16敲低和过表达实验，研究发现核内IFI16在疱疹病毒感染早期通过激活IRF-3信号通路抑制病毒复制，强调了其作为DNA传感器的双重功能(促炎与抗病毒)。
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4. **文献名称**: *"Autoimmune diseases linked to the IFI16-related innate immune sensor pathway"*
**作者**: Mondini M 等
**摘要**: 该研究通过免疫组化(使用抗IFI16抗体)和血清学分析，证明系统性红斑狼疮(SLE)患者中IFI16的异常表达与自身抗体产生相关，提示IFI16可能是自身免疫疾病的潜在生物标志物。
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**提示**：以上为示例性内容，具体文献需通过PubMed、Google Scholar等平台以关键词“IFI16 antibody”或“IFI16 function”检索。推荐结合实验目的(如病毒免疫、自身免疫疾病或癌症)筛选近年高引用论文。
IFI16 antibody is a research tool targeting the interferon-inducible protein 16 (IFI16), a member of the PYHIN protein family. IFI16 is a nuclear and cytoplasmic sensor involved in innate immune responses, particularly in detecting pathogenic DNA from viruses and bacteria. It plays roles in regulating inflammation, cell cycle control, apoptosis, and antiviral defense by activating pathways like STING and NF-κB. The protein contains two HIN domains for DNA binding and a Pyrin domain for protein interactions.
Antibodies against IFI16 are widely used to study its expression, localization, and function in diseases. Elevated IFI16 levels are linked to autoimmune disorders (e.g., systemic lupus erythematosus), cancers, and chronic viral infections (e.g., HPV, HIV). In autoimmune contexts, IFI16 autoantibodies serve as biomarkers. Researchers also explore IFI16's role in viral restriction, inflammasome activation, and tumor suppression. Commercial IFI16 antibodies enable applications like Western blot, immunofluorescence, and immunohistochemistry, aiding mechanistic studies and therapeutic development. However, antibody specificity and cross-reactivity with homologous proteins (e.g., AIM2) require careful validation in experimental settings.
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