| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Galactoside 3(4)-L-fucosyltransferase; Blood group Lewis alpha-4-fucosyltransferase; Lewis FT; Fucosyltransferase 3; FucT-III |
| Entrez GeneID | 2525; |
| WB Predicted band size | 42kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human FUT3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FUT3抗体的假设性参考文献示例(仅供格式参考，具体文献需通过学术数据库核实)：
1. **文献名称**：*FUT3-mediated Lewis antigen expression in colorectal cancer progression*
**作者**：Smith A, et al.
**摘要**：研究揭示了FUT3基因在结直肠癌中通过调控Lewis抗原表达促进肿瘤转移的机制，并利用FUT3抗体通过免疫组化验证其蛋白表达水平与患者预后负相关。
2. **文献名称**：*Development of a monoclonal antibody targeting FUT3 for serum biomarker detection*
**作者**：Chen L, et al.
**摘要**：报道一种新型FUT3单克隆抗体的开发，通过ELISA技术检测血清中Lewis抗原，证明其在胰腺癌早期诊断中的潜在应用价值。
3. **文献名称**：*FUT3 knockdown suppresses gastric cancer cell adhesion via antibody-blocking experiments*
**作者**：Yamamoto K, et al.
**摘要**：利用FUT3抗体阻断胃癌细胞表面Lewis抗原，证实其通过影响整合素信号通路抑制癌细胞黏附和侵袭能力。
4. **文献名称**：*Differential FUT3 expression in inflammatory bowel disease revealed by antibody-based profiling*
**作者**：Müller S, et al.
**摘要**：通过组织芯片和FUT3抗体染色，发现FUT3在溃疡性结肠炎患者的肠上皮中异常高表达，提示其参与黏膜炎症反应调控。
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**注意**：以上文献信息为模拟数据，实际引用需查询PubMed/Web of Science等平台(可尝试关键词：FUT3 antibody, Lewis antigen, cancer biomarker)。如需真实文献，请提供数据库访问权限或具体研究方向进一步筛选。
**Background of FUT3 Antibody**
The FUT3 antibody targets the protein product of the *FUT3* gene, which encodes α1.3/4-fucosyltransferase (also known as Lewis enzyme). This enzyme catalyzes the transfer of fucose residues to glycan structures, forming Lewis blood group antigens (e.g., Lewis a/b and sialyl Lewis x/a). These antigens are critical in cell-cell interactions, immune responses, and pathogen adhesion. FUT3 is highly expressed in epithelial tissues and plays roles in inflammation, cancer metastasis, and microbial recognition.
Dysregulation of FUT3 is linked to diseases such as cancer (e.g., colorectal, pancreatic), where altered Lewis antigen expression affects tumor cell adhesion and immune evasion. FUT3 antibodies are vital tools in research to study glycosylation changes in malignancies, inflammatory conditions (e.g., Crohn’s disease), and host-microbe interactions. They enable detection of Lewis antigen distribution in tissues or cells via techniques like immunohistochemistry, flow cytometry, or Western blot.
Clinically, FUT3 antibodies have potential diagnostic and prognostic value, as Lewis antigen profiles correlate with tumor aggressiveness and metastatic potential. Additionally, they aid in understanding genetic variations (e.g., *FUT3* polymorphisms) influencing disease susceptibility or therapeutic responses. Overall, FUT3 antibodies bridge glycoscience with pathophysiology, offering insights into targeted therapies and biomarker discovery.
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