Rabbit Polyclonal EIF3D Antibody

The eukaryotic translation initiation factor 3 subunit D (EIF3D) is a critical component of the EIF3 complex, a multi-protein assembly essential for initiating mRNA translation in eukaryotes. EIF3D, a ~65 kDa protein encoded by the EIF3D gene on human chromosome 22q12.2. binds to the 40S ribosomal subunit and facilitates recruitment of mRNA and other initiation factors. Unlike other EIF3 subunits, EIF3D uniquely exhibits RNA-binding properties and may regulate the translation of specific mRNAs, particularly those with complex 5' untranslated regions. Studies suggest its involvement in cell proliferation, apoptosis, and tumorigenesis, with overexpression observed in cancers like hepatocellular carcinoma and glioblastoma. EIF3D antibodies are vital tools for investigating its expression, localization, and interactions in translational regulation. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence. Recent research highlights EIF3D's non-canonical roles, including potential extraribosomal functions in viral infection responses and stress granule dynamics. However, its precise mechanistic contributions remain under exploration. Validated EIF3D antibodies help dissect its dual roles in canonical translation and disease-associated pathways, making them valuable for both basic research and translational oncology studies.