| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Epsin-3; EPS-15-interacting protein 3; |
| Entrez GeneID | 55040; |
| WB Predicted band size | 68kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human EPN3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于EPN3抗体的3篇示例参考文献(注：文献为虚构示例，实际引用需查询真实数据库)：
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1. **文献名称**：*EPN3 Antibody Characterization and Its Role in Clathrin-Mediated Endocytosis*
**作者**：Chen L, Wang Y, et al.
**摘要**：本研究开发了一种高特异性EPN3多克隆抗体，验证了其在免疫印迹和免疫荧光中的应用。结果证实EPN3通过与网格蛋白协同作用调控细胞膜内吞过程，影响受体介导的信号转导。
2. **文献名称**：*Overexpression of Epsin3 in Colorectal Cancer and Its Correlation with Metastasis*
**作者**：Tanaka R, Sato M, et al.
**摘要**：通过EPN3抗体进行免疫组化分析，发现结直肠癌组织中EPN3表达显著上调，且与淋巴结转移呈正相关。机制研究表明EPN3通过调控Wnt/β-catenin通路促进肿瘤侵袭。
3. **文献名称**：*Structural Insights into EPN3-Ligand Interactions Using Monoclonal Antibody Blockade*
**作者**：Gupta S, Roberts T, et al.
**摘要**：利用新型EPN3单克隆抗体解析其与Ubiquitin的结合域，揭示EPN3通过泛素化依赖的途径参与溶酶体降解过程，为靶向蛋白降解药物开发提供依据。
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如需实际文献，建议在PubMed或Web of Science中以“EPN3 antibody”或“Epsin3 function”为关键词检索，并筛选近年研究。
**Background of EPN3 Antibody**
EPN3 (Epsin-3) is a member of the epsin family, adaptor proteins involved in membrane trafficking and clathrin-mediated endocytosis. It contains an N-terminal ENTH (epsin N-terminal homology) domain, which binds to phosphatidylinositol lipids, and C-terminal motifs that interact with clathrin, AP-2 adaptors, and ubiquitinated cargo. EPN3 is distinct from other epsins (e.g., EPN1. EPN2) due to its restricted expression, primarily observed in specific tissues like gastric mucosa and certain cancers.
Research highlights EPN3's role in cancer progression, particularly in tumorigenesis and metastasis. It is overexpressed in malignancies such as breast, gastric, and colorectal cancers, where it promotes cell invasion, survival, and drug resistance by modulating receptor signaling (e.g., EGFR) and endocytic pathways. EPN3 antibodies are essential tools for detecting its expression and localization in cells or tissues via techniques like Western blotting, immunohistochemistry, or immunofluorescence. These antibodies help elucidate EPN3's functional mechanisms, including its interplay with oncogenic signaling networks and potential as a therapeutic target. Recent studies also explore its involvement in Golgi-related trafficking and epithelial-mesenchymal transition (EMT), further underscoring its relevance in cellular dynamics and disease.
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