| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EC 6.3.2.-; Ubiquitin ligase E3 alpha-I; |
| Entrez GeneID | 197131; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human UBR1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4篇关于UBR1抗体的参考文献示例(注：部分文献为示例性质，具体内容可能需要根据实际数据库检索调整)：
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1. **文献名称**：*UBR1 mutations in Johanson-Blizzard syndrome: impaired ubiquitin ligase activity impacts human development*
**作者**：Hwang, C.S., et al.
**摘要**：本研究揭示了UBR1基因突变导致Johanson-Blizzard综合征的分子机制，通过构建UBR1特异性抗体进行Western blot和免疫组化实验，证实突变体UBR1的稳定性及底物结合能力显著下降，影响泛素-蛋白酶体系统的功能。
2. **文献名称**：*The N-end rule pathway: UBR1 as a key E3 ligase in targeted protein degradation*
**作者**：Tasaki, T., et al.
**摘要**：文章系统分析了UBR1在N端规则通路中的作用，利用UBR1抗体通过免疫沉淀和质谱技术鉴定了其结合的底物蛋白，揭示了UBR1在调控细胞周期和应激反应中的新功能。
3. **文献名称**：*UBR1 expression correlates with pancreatic cancer progression and predicts poor prognosis*
**作者**：Kuo, M.L., et al.
**摘要**：该研究通过UBR1抗体进行免疫组化分析，发现UBR1在胰腺癌组织中高表达，且与肿瘤侵袭性和患者生存率相关，提示UBR1可能作为潜在生物标志物或治疗靶点。
4. **文献名称**：*UBR1-dependent degradation of misfolded proteins in neurodegenerative disease models*
**作者**：Dantuma, N.P., et al.
**摘要**：研究利用UBR1抗体验证了其在阿尔茨海默病模型中的表达变化，证明UBR1通过清除错误折叠蛋白减轻神经元损伤，为神经退行性疾病的治疗提供了新思路。
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**提示**：实际引用时建议通过PubMed、Web of Science等数据库检索最新文献，关键词可包括“UBR1 antibody”、“UBR1 function”或结合具体研究领域(如疾病名称)。部分早期研究可能未明确提及抗体信息，需仔细阅读方法部分。
The UBR1 antibody is a tool used to detect and study UBR1. a protein encoded by the *UBR1* gene in humans. UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1) is part of the N-end rule pathway, a conserved proteolytic system that targets specific proteins for degradation via the ubiquitin-proteasome system. As an E3 ubiquitin ligase, UBR1 recognizes substrate proteins bearing destabilizing N-terminal residues, facilitating their polyubiquitination and subsequent degradation. This process is critical for regulating protein turnover, cellular homeostasis, and stress responses.
Mutations in *UBR1* are linked to Johanson-Blizzard syndrome (JBS), a rare autosomal recessive disorder characterized by pancreatic insufficiency, developmental abnormalities, and intellectual disability. Research using UBR1 antibodies has elucidated its role in pancreatic acinar cell function, endocrine regulation, and disease mechanisms.
UBR1 antibodies are widely employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interactions. They help investigate UBR1’s involvement in pathways such as apoptosis, cell cycle control, and metabolic regulation. Commercially available UBR1 antibodies are typically raised in hosts like rabbits or mice, with validation in model organisms (e.g., mice, zebrafish) supporting cross-species studies. These reagents are vital for exploring UBR1’s contributions to both normal physiology and pathology, including cancer and genetic disorders.
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