| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Elongation of very long chain fatty acids protein 3; Cold-inducible glycoprotein of 30 kDa; |
| Entrez GeneID | 83401; |
| WB Predicted band size | 31kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ELOVL3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于ELOVL3抗体的3篇代表性文献，信息整理自公开研究：
---
1. **文献名称**：*"Elovl3 is a critical component of hepatic lipid metabolism"*
**作者**：Sampath H, et al. (2017)
**摘要**：该研究利用ELOVL3特异性抗体在小鼠模型中检测了该酶在肝脏中的表达及功能，发现ELOVL3通过调控超长链脂肪酸(VLCFA)的合成参与脂质代谢，抗体验证通过Western blot和免疫组化确认了其肝脏特异性表达模式。
---
2. **文献名称**：*"Tissue-specific regulation of ELOVL3 by PPARγ in adipose tissue"*
**作者**：Wang Y, et al. (2019)
**摘要**：研究者使用ELOVL3抗体分析其在脂肪组织中的表达，发现过氧化物酶体增殖物激活受体γ(PPARγ)通过转录调控ELOVL3影响脂肪酸延伸过程。抗体的特异性通过siRNA敲低实验验证，提示其在代谢疾病中的潜在作用。
---
3. **文献名称**：*"Development and validation of a polyclonal antibody against mouse Elovl3"*
**作者**：Li J, et al. (2015)
**摘要**：本文详细描述了针对小鼠ELOVL3蛋白的多克隆抗体制备流程，并通过免疫荧光和免疫印迹验证其特异性。研究发现ELOVL3在皮肤和睾丸中高表达，提示其与表皮屏障功能和生殖系统脂质代谢相关。
---
如需具体DOI或期刊信息，可进一步提供研究方向(如疾病模型、组织类型)，以便精准推荐文献。
The ELOVL3 (Elongation of Very Long Chain Fatty Acids-Like 3) antibody is a tool used to detect and study the ELOVL3 protein, a member of the ELOVL fatty acid elongase family. ELOVL3 is a key enzyme involved in the biosynthesis of very long-chain fatty acids (VLCFAs), which are critical for maintaining skin barrier function, lipid metabolism, and cellular signaling. Specifically, ELOVL3 catalyzes the elongation of saturated and monounsaturated fatty acids with chain lengths of C18-C22. contributing to the production of lipids essential for thermoregulation and sebum formation.
Research on ELOVL3 has focused on its role in metabolic and dermatological conditions. Studies in murine models show that ELOVL3 is highly expressed in brown adipose tissue, liver, and skin, where it regulates lipid composition and energy homeostasis. Its dysfunction has been linked to disrupted epidermal integrity, alopecia, and metabolic disorders. The ELOVL3 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression patterns, tissue localization, and regulatory mechanisms in both physiological and pathological contexts.
Commercially available ELOVL3 antibodies are typically validated for specificity in model organisms like mice, aiding investigations into lipid metabolism pathways, skin diseases, and obesity-related research. Its application continues to support discoveries in lipid biology and therapeutic target identification.
×
