| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | cPLA2-gamma; cytosolic phospholipase A2 gamma precursor; phospholipase A2 group IVC; |
| Entrez GeneID | 8605; |
| WB Predicted band size | 70kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human PLA2G4C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于PLA2G4C抗体的3篇参考文献(基于虚拟合成内容，仅供参考)：
1. **标题**: *Characterization of a Novel Monoclonal Antibody Against Human PLA2G4C*
**作者**: Smith A, et al.
**摘要**: 开发了一种针对PLA2G4C蛋白的单克隆抗体，验证其在Western blot和免疫荧光中的特异性，证实其在多种组织中的表达差异，为PLA2G4C功能研究提供工具。
2. **标题**: *PLA2G4C Expression in Inflammatory Diseases: Insights from Immunohistochemical Analysis*
**作者**: Lee B, et al.
**摘要**: 利用商业化PLA2G4C抗体研究其在类风湿性关节炎和动脉粥样硬化病变组织中的表达，发现其与炎症介质关联，提示其可能参与脂质信号通路调控。
3. **标题**: *Functional Role of PLA2G4C in Cancer Progression Revealed by Antibody-Based Inhibition*
**作者**: Tanaka K, et al.
**摘要**: 通过PLA2G4C中和抗体抑制其活性，发现可降低癌细胞迁移能力，表明该酶通过调节花生四烯酸代谢促进肿瘤侵袭，为潜在治疗靶点提供证据。
注：以上文献为示例，实际研究中请通过PubMed或Web of Science检索具体文献。
The PLA2G4C antibody targets the phospholipase A2 group IVC (PLA2G4C) enzyme, a member of the cytosolic phospholipase A2 (cPLA2) family. This enzyme is encoded by the PLA2G4C gene and plays a role in lipid metabolism by catalyzing the hydrolysis of phospholipids to release free fatty acids, including arachidonic acid, a precursor for pro-inflammatory signaling molecules like prostaglandins and leukotrienes. Unlike other cPLA2 isoforms (e.g., PLA2G4A), PLA2G4C has a unique structural organization, lacking a calcium-binding domain, which suggests distinct regulatory mechanisms or functional roles in specific tissues.
PLA2G4C is expressed in select tissues, including the skin, testes, and certain immune cells, though its physiological and pathological roles remain less characterized compared to other PLA2 isoforms. Antibodies against PLA2G4C are essential tools for detecting its expression and localization in experimental models, aiding studies on its involvement in inflammatory responses, cellular membrane remodeling, and lipid-mediated signaling. Research has also explored its potential links to cancer progression, neurodegenerative disorders, and autoimmune diseases.
These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Validating their specificity is critical due to structural similarities among PLA2 family members. Ongoing research aims to clarify PLA2G4C's biological significance and therapeutic potential in disease contexts.
×
