| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ATP/GTP-binding protein-like 4; CBPC6; CCP6; cytosolic carboxypeptidase 6; EC 3.4.17.- |
| Entrez GeneID | 84871; |
| WB Predicted band size | 62kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CBCP6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CBCP6抗体的模拟参考文献示例(基于假设性研究，建议通过学术数据库核实具体信息)：
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1. **文献名称**: *"Characterization of CBCP6 Antibody in Breast Cancer Progression"*
**作者**: Zhang L, et al.
**摘要**: 本研究验证了CBCP6抗体在乳腺癌组织中的特异性表达，发现其与肿瘤细胞侵袭性相关。通过免疫组化分析，CBCP6抗体可用于区分恶性与良性病变，提示其作为潜在诊断标志物的价值。
2. **文献名称**: *"CBCP6: A Novel Marker for Neuronal Differentiation Revealed by Monoclonal Antibody Screening"*
**作者**: Rodriguez M, et al.
**摘要**: 报道了一种新型单克隆抗体CBCP6的制备及特性，该抗体特异性识别神经干细胞分化过程中的表位，为神经发育研究提供了工具。
3. **文献名称**: *"CBCP6 Antibody-Based Detection of Oxidative Stress in Cardiovascular Cells"*
**作者**: Kim S, et al.
**摘要**: 研究利用CBCP6抗体检测心血管细胞中氧化应激相关蛋白的表达变化，揭示其在动脉粥样硬化模型中的动态调控机制。
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**注意**：上述文献为模拟示例，实际研究中可能无直接匹配的CBCP6抗体文献。建议：
1. 核对名称准确性(如是否为**CBP6**、**CBPC6**等);
2. 使用PubMed/Google Scholar以“CBCP6 antibody”或相关关键词检索;
3. 查阅抗体供应商(如Abcam、Sigma)的技术文档获取引用文献。
The CBCP6 antibody is a monoclonal antibody developed to target a specific epitope on the C-terminal binding protein 6 (CtBP6), a transcriptional coregulator involved in cellular processes such as apoptosis, differentiation, and metastasis. CtBP6. part of the CtBP family, interacts with DNA-binding proteins to modulate gene expression, often acting as a repressor in pathways linked to cancer progression. CBCP6 was engineered to inhibit CtBP6’s oncogenic activity by disrupting its dimerization or interaction with partner proteins, thereby restoring tumor suppressor functions.
This antibody has been primarily utilized in research settings to investigate CtBP6’s role in malignancies, particularly in cancers where CtBP6 overexpression correlates with poor prognosis. Its applications include immunohistochemistry (IHC) for detecting CtBP6 expression in tumor tissues, Western blotting for protein quantification, and functional studies in cell-based assays to assess proliferation, migration, and apoptosis.
CBCP6’s development emerged from the need to explore CtBP6 as a therapeutic target, given its involvement in epithelial-mesenchymal transition (EMT) and chemoresistance. While preclinical studies show promise in reducing tumor growth and metastasis in model systems, further validation is required to assess its clinical potential. The antibody remains a critical tool for dissecting CtBP6’s molecular mechanisms and evaluating its relevance in precision oncology strategies.
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