| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 'nucleotidase; cytosolic IA; 5NT1A; CN-I; CN-IA |
| Entrez GeneID | 84618; |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human NT5C1A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NT5C1A抗体的3条参考文献示例(注：以下内容为模拟生成，实际文献需根据具体数据库查询)：
1. **文献名称**：*Autoantibodies against NT5C1A in idiopathic inflammatory myopathies*
**作者**：Smith A, Jones B
**摘要**：该研究报道了在特发性炎性肌病(如皮肌炎和多发性肌炎)患者血清中检测到NT5C1A自身抗体，提示其可能作为疾病特异性生物标志物，并探讨了抗体水平与疾病活动度的相关性。
2. **文献名称**：*NT5C1A overexpression promotes chemoresistance in acute lymphoblastic leukemia*
**作者**：Chen X, Wang Y
**摘要**：研究揭示了NT5C1A在急性淋巴细胞白血病(ALL)中的高表达现象，证实其通过调节核苷酸代谢通路导致化疗药物耐药性，并开发了一种特异性抗体用于临床样本中NT5C1A的蛋白水平检测。
3. **文献名称**：*Structural and functional characterization of human NT5C1A using monoclonal antibodies*
**作者**：Lee S, Kim T
**摘要**：通过制备高特异性单克隆抗体，本研究解析了NT5C1A的酶活性结构域，并证明其在胞内嘌呤代谢中的关键作用，为靶向NT5C1A的抑制剂开发提供了实验基础。
(如需真实文献，建议通过PubMed或Google Scholar以“NT5C1A antibody”、“NT5C1A autoantibody”等关键词检索。)
The NT5C1A antibody targets the protein NT5C1A (5'-nucleotidase, cytosolic IA), a member of the 5'-nucleotidase family involved in nucleotide metabolism. NT5C1A catalyzes the dephosphorylation of nucleoside monophosphates, such as CMP and UMP, regulating intracellular nucleotide pools critical for DNA/RNA synthesis and cellular homeostasis. This enzyme plays roles in cell proliferation, differentiation, and survival, with dysregulation linked to pathological conditions.
Research highlights NT5C1A's overexpression in certain cancers, including chronic lymphocytic leukemia (CLL), where it may promote drug resistance by altering nucleotide balance. It is also implicated in autoimmune disorders, such as rheumatoid arthritis, potentially due to its role in immune cell activation. NT5C1A antibodies are essential tools for detecting protein expression levels, localization, and functional studies in these contexts. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding investigations into NT5C1A's mechanistic contributions to disease pathways.
Recent studies explore NT5C1A as a biomarker or therapeutic target, particularly in hematologic malignancies. Mutations or aberrant expression of NT5C1A may influence clinical outcomes, driving interest in its molecular interactions and regulatory networks. The antibody's specificity ensures accurate profiling in both normal and diseased tissues, supporting translational research aimed at understanding its pathophysiological significance.
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