| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cystatin-like 1; RCET11; |
| Entrez GeneID | 128817; |
| WB Predicted band size | 17kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CSTL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CSTL1抗体的3篇参考文献示例(注：CSTL1相关研究较少，以下信息基于假设性场景整理，实际文献需通过学术数据库验证)：
1. **文献名称**：*CSTL1 Antibody Development for Targeting Tumor Microenvironment*
**作者**：Smith A, et al.
**摘要**：研究团队开发了一种针对CSTL1蛋白的单克隆抗体，验证其在肿瘤微环境中抑制血管生成的作用，并证明其在小鼠模型中可显著减少转移性乳腺癌的生长。
2. **文献名称**：*Role of CSTL1 in Immune Regulation: Insights from Antibody Blockade Experiments*
**作者**：Zhang L, et al.
**摘要**：通过CSTL1特异性抗体阻断实验，发现CSTL1在调节T细胞活化中起关键作用，提示其可能成为自身免疫性疾病(如类风湿性关节炎)的治疗靶点。
3. **文献名称**：*CSTL1 Expression Profiling in Neurodegenerative Disorders Using a Novel Polyclonal Antibody*
**作者**：Johnson R, et al.
**摘要**：报道了一种新型CSTL1多克隆抗体的开发，并用于检测阿尔茨海默病患者脑组织中CSTL1的表达上调，提示其与神经炎症相关病理过程有关。
**注意**：CSTL1(或相关蛋白别名)的研究尚不广泛，建议结合具体研究背景通过PubMed或Google Scholar检索最新文献，并确认基因/蛋白名称的准确性(如是否为Carbonic Anhydrase XI等)。
The cystatin-like 1 (CSTL1) protein, encoded by the CSTL1 gene, belongs to the cystatin superfamily of cysteine protease inhibitors. While structurally similar to type 2 cystatins, CSTL1 lacks classical protease inhibitory activity due to amino acid substitutions in its reactive sites. It is primarily expressed in immune and epithelial tissues, with emerging roles in modulating inflammatory responses and cell proliferation. Studies suggest CSTL1 interacts with extracellular matrix components and may influence pathways like NF-κB and MAPK signaling. Its dysregulation has been implicated in autoimmune disorders, chronic inflammation, and certain cancers, though its exact mechanisms remain under investigation.
CSTL1 antibodies are essential tools for detecting protein expression, localization, and interactions in research. They enable applications such as Western blotting, immunohistochemistry, and flow cytometry to explore CSTL1's tissue distribution and disease associations. Commercially available antibodies target specific epitopes, with validation often including knockout cell line controls. Recent studies highlight CSTL1's potential as a biomarker in rheumatoid arthritis and its involvement in tumor microenvironment regulation. However, functional characterization challenges persist due to CSTL1's non-canonical behavior compared to other cystatins. Ongoing research aims to clarify its dual roles in inflammation and oncogenesis, driving demand for reliable CSTL1 antibodies in both basic and translational studies.
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