| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cystatin-11; |
| Entrez GeneID | 140880; |
| WB Predicted band size | 17kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CST11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CST11抗体的模拟参考文献示例(实际文献需通过学术数据库查询)：
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1. **文献名称**: *CST11 Antibody Characterization and Its Role in Immune Regulation*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种针对人CST11蛋白的高特异性多克隆抗体，验证了其在Western blot和免疫组化中的应用，并发现CST11在调节巨噬细胞炎症反应中的潜在作用。
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2. **文献名称**: *CST11 Expression in Male Reproductive System: A Monoclonal Antibody-Based Study*
**作者**: Chen L, et al.
**摘要**: 通过构建CST11单克隆抗体，揭示了其在睾丸组织中的特异性表达模式，提示CST11可能与精子发生及男性生殖功能相关。
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3. **文献名称**: *CST11 as a Biomarker in Colorectal Cancer: Validation via Immunohistochemistry*
**作者**: Wang Y, et al.
**摘要**: 利用商业化CST11抗体进行组织芯片分析，发现CST11在结直肠癌组织中高表达，且与患者预后不良显著相关，表明其作为癌症标志物的潜力。
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4. **文献名称**: *Role of CST11 in Epithelial Barrier Function: Insights from Knockout Models*
**作者**: Gupta R, et al.
**摘要**: 采用CST11抗体检测基因敲除小鼠模型，证实CST11通过调控紧密连接蛋白维持肠道上皮屏障完整性，可能影响炎症性肠病的发展。
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**提示**：以上为模拟示例，实际文献请通过PubMed、Web of Science或Google Scholar等平台检索关键词“CST11 antibody”或“Cystatin 11 antibody”获取。
CST11 antibody is a research tool designed to detect and study the Cystatin 11 (CST11) protein, a member of the type 2 cystatin family. Cystatins are natural inhibitors of cysteine proteases, enzymes involved in protein degradation, immune responses, and cellular processes. CST11. specifically, is a small secretory protein encoded by the *CST11* gene and is primarily expressed in reproductive tissues, such as the epididymis and testes, suggesting roles in sperm maturation and fertility. It may also participate in immune regulation and epithelial defense due to its interaction with proteases in mucosal environments.
The CST11 antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to localize and quantify CST11 expression in biological samples. Researchers employ it to explore CST11’s physiological functions, tissue-specific distribution, and potential involvement in diseases, including reproductive disorders or cancers. Polyclonal or monoclonal CST11 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the protein. Validation steps, such as knockdown controls or peptide blocking assays, ensure specificity. Its development aids in understanding protease regulation pathways and may contribute to diagnostic or therapeutic advancements in reproductive health and immunopathology.
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