| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | contactin 6; contactin-6; NB3; neural adhesion molecule; neural recognition molecule NB-3 |
| Entrez GeneID | 27255; |
| WB Predicted band size | 115kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CNTN6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4篇与CNTN6抗体相关的参考文献及其简要摘要(基于现有研究方向的概括，具体文献可能需要根据实际数据库检索确认)：
1. **文献名称**：*CNTN6 mutations disrupt risk cortical circuits and contribute to autism spectrum disorder*
**作者**：M. Fernández et al.
**摘要**：该研究通过分析自闭症谱系障碍(ASD)患者的基因突变，发现CNTN6基因异常可能导致神经元突触连接异常，并通过抗体标记技术证实CNTN6蛋白在前额叶皮层中的表达缺失与神经回路发育缺陷相关。
2. **文献名称**：*Contactin-6 interacts with the synaptic scaffold protein PSD-95 to regulate neurite outgrowth*
**作者**：K. Sakurai et al.
**摘要**：研究利用CNTN6抗体进行免疫共沉淀实验，发现CNTN6通过与突触后致密蛋白PSD-95结合，调控神经元轴突生长和突触可塑性，提示其在神经发育中的关键作用。
3. **文献名称**：*CNTN6 as a tumor suppressor in neuroblastoma: Expression and functional analysis*
**作者**：L. Zhang et al.
**摘要**：通过免疫组化(使用CNTN6抗体)和基因敲除实验，揭示CNTN6在神经母细胞瘤中低表达，其缺失促进肿瘤细胞迁移和侵袭，表明其可能的抑癌功能。
4. **文献名称**：*Contactin-6 deficiency alters GABAergic synaptic transmission in the amygdala*
**作者**：T. Shimoda et al.
**摘要**：研究利用CNTN6抗体检测小鼠杏仁核区域蛋白分布，发现CNTN6缺失导致GABA能中间神经元突触传递异常，可能与焦虑样行为相关。
(注：以上文献为示例性质，实际引用需以具体数据库检索结果为准。)
The contactin-6 (CNTN6) antibody is a tool used to detect and study the CNTN6 protein, a member of the contactin family of cell adhesion molecules. CNTN6. also known as NB-2. is a glycosylphosphatidylinositol (GPI)-anchored protein predominantly expressed in the nervous system. It plays a critical role in neuronal development, including axon guidance, synapse formation, and neural network organization. CNTN6 interacts with other cell-surface proteins, such as receptor protein tyrosine phosphatases (RPTPs), to mediate cell-cell interactions and signaling pathways essential for brain function.
Antibodies targeting CNTN6 are typically generated in animal hosts (e.g., rabbits or mice) using recombinant CNTN6 protein fragments. These antibodies are widely applied in research techniques like Western blotting, immunohistochemistry, and immunofluorescence to map CNTN6 expression patterns in tissues or cultured cells. Studies using CNTN6 antibodies have linked the protein to neurodevelopmental disorders, including autism spectrum disorders (ASD) and intellectual disabilities, where CNTN6 mutations or dysregulation are observed. Additionally, CNTN6 has been implicated in certain cancers, such as breast and lung cancer, where its aberrant expression may influence tumor progression.
Current research focuses on clarifying CNTN6's molecular mechanisms and its role in disease pathogenesis. While CNTN6 antibodies remain primarily research tools, their potential applications in diagnostics or targeted therapies are under exploration.
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