| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Contactin-2; Axonin-1; Axonal glycoprotein TAG-1; Transient axonal glycoprotein 1; TAX-1 |
| Entrez GeneID | 6900; |
| WB Predicted band size | 120kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human CNTN2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CNTN2抗体的3篇代表性文献概览(基于公开信息模拟整理，非真实文献)：
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1. **文献名称**: *Autoantibodies to Contactin-2 in Neurological Disorders*
**作者**: Smith A, et al.
**摘要**: 研究发现在部分多发性硬化症(MS)和视神经脊髓炎患者血清中检测到抗CNTN2抗体，提示该抗体可能通过干扰轴突-胶质细胞相互作用参与脱髓鞘疾病的病理过程。
2. **文献名称**: *CNTN2 Antibody-mediated Disruption of Neuronal Adhesion in Autism Spectrum Models*
**作者**: Chen L, et al.
**摘要**: 通过体外实验和小鼠模型证明，CNTN2抗体会抑制神经元突触形成和细胞黏附，可能与自闭症谱系障碍(ASD)相关的神经发育异常存在关联。
3. **文献名称**: *The Role of Anti-CNTN2 in Paraneoplastic Neurological Syndromes*
**作者**: Tanaka K, et al.
**摘要**: 报道了在副肿瘤性小脑变性患者中发现抗CNTN2抗体，提示该抗体可能作为特定肿瘤(如肺癌)相关的神经副肿瘤综合征的生物标志物。
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**注意**：以上文献信息为示例性模拟，实际研究中请通过PubMed或Google Scholar以关键词“CNTN2 antibody”或“Contactin-2 autoantibody”检索真实文献。
CNTN2 (Contactin-2), also known as Axonin-1 or TAG-1. is a cell adhesion molecule belonging to the immunoglobulin superfamily. It plays a critical role in nervous system development, including axon guidance, myelination, and synaptic plasticity. CNTN2 is predominantly expressed in neurons and glial cells, where it facilitates cell-cell interactions through homophilic or heterophilic binding with partners like Contactin-1 or L1CAM. Its involvement in neural network formation makes it a key focus in neurodevelopmental and neurodegenerative studies.
Antibodies targeting CNTN2 are essential tools for investigating its expression, localization, and function. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize CNTN2 distribution in tissues or cultured cells. Researchers also employ CNTN2 antibodies to explore its role in diseases. For instance, altered CNTN2 expression has been linked to autism spectrum disorders, schizophrenia, and multiple sclerosis, suggesting its potential as a biomarker or therapeutic target. Additionally, CNTN2 is implicated in cancer progression, particularly in metastasis and neural invasion in certain tumors.
Commercial CNTN2 antibodies are typically raised in hosts like rabbits or mice, with validation across species such as human, mouse, and rat. Specificity and batch consistency are critical considerations, as cross-reactivity with other contactin family members may occur. Recent studies also utilize CNTN2 antibodies in advanced applications like single-cell RNA sequencing validation or CRISPR-edited cell line characterization, reflecting its growing relevance in precision neurobiology and oncology research.
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