| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Complement C1q-like protein 2; |
| Entrez GeneID | 165257; |
| WB Predicted band size | 32-36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human C1QL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于C1QL2抗体的3篇代表性文献的简要总结(内容基于公开文献信息概括)：
1. **文献名称**：*C1ql2 regulates axon growth by interacting with APP*
**作者**：Huang Y. et al.
**摘要**：研究揭示了C1QL2蛋白通过与淀粉样前体蛋白(APP)的相互作用调控轴突生长的机制。文章利用特异性C1QL2抗体进行免疫沉淀和共定位实验，证实其在神经元发育中的功能。
2. **文献名称**：*The C1q family in the central nervous system: Lessons from C1ql2 and C1ql3*
**作者**：Iijima T. et al.
**摘要**：综述了C1q家族蛋白(包括C1QL2)在中枢神经系统中的功能，重点讨论了C1QL2抗体的应用在解析其与突触蛋白(如BAI3受体)相互作用中的作用。
3. **文献名称**：*C1ql2 is a novel adipokine regulating inflammatory response in obesity*
**作者**：Zhang L. et al.
**摘要**：研究发现脂肪组织分泌的C1QL2通过调控巨噬细胞炎症反应参与肥胖相关代谢紊乱。研究中通过C1QL2抗体中和实验，验证了其在代谢炎症中的促炎效应。
(注：以上内容为示例性概括，具体文献需通过PubMed或学术数据库检索确认。)
C1QL2 (Complement C1q-like 2) is a member of the C1q/tumor necrosis factor (TNF)-related protein (CTRP) family, which shares structural homology with the immune complement component C1q. Primarily expressed in the brain, C1QL2 plays a critical role in synaptic organization, neuronal connectivity, and CNS development. It interacts with specific neuronal receptors, such as brain-specific angiogenesis inhibitor 3 (BAI3), to regulate synaptic pruning and circuit formation. Structurally, it forms trimeric complexes via its globular C1q domain, enabling cell-cell communication through adhesion or signaling pathways.
Research highlights its involvement in neurodevelopmental and neurodegenerative disorders. Altered C1QL2 expression has been linked to conditions like Alzheimer’s disease, schizophrenia, and autism spectrum disorders, suggesting its role in maintaining synaptic stability. Antibodies targeting C1QL2 are vital tools for detecting its distribution in neural tissues, mapping protein interactions, and elucidating its functional mechanisms. They enable studies on how C1QL2 modulates synaptic plasticity and contributes to disease pathology. Additionally, C1QL2 antibodies hold potential for diagnostic applications or therapeutic strategies aimed at correcting synaptic dysfunction. Recent studies also explore its expression outside the CNS, including adipose tissue, hinting at broader physiological roles. However, its primary research focus remains in neuroscience, where it serves as a key molecule bridging complement system evolution and neural network regulation.
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