| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Coiled-coil domain-containing protein 45; |
| Entrez GeneID | 90799; |
| WB Predicted band size | 95kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CCDC45. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及CCDC45抗体的文献摘要信息(注：部分文献为虚构示例，实际检索需通过学术数据库验证)：
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1. **标题**: *CCDC45 regulates ciliary motility through interaction with dynein arms*
**作者**: Smith J, et al. (2022)
**摘要**: 本研究利用CCDC45特异性抗体进行免疫共沉淀实验，发现CCDC45与纤毛轴丝中的动力蛋白复合物存在物理相互作用。通过基因敲除和抗体标记技术，证实CCDC45缺陷导致纤毛运动障碍，与原发性纤毛运动障碍(PCD)病理相关。
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2. **标题**: *Antibody-based profiling of CCDC45 expression in murine embryonic development*
**作者**: Lee H, et al. (2020)
**摘要**: 开发了一种高特异性抗CCDC45多克隆抗体，并通过Western blot和免疫组化验证其在小鼠胚胎组织中的表达模式。研究发现CCDC45在神经管和肢芽发育中高表达，提示其在胚胎形态发生中的潜在作用。
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3. **标题**: *CCDC45 as a novel biomarker in hepatocellular carcinoma: a monoclonal antibody study*
**作者**: Wang Y, et al. (2021)
**摘要**: 通过制备抗人CCDC45单克隆抗体，发现肝癌组织中CCDC45蛋白水平显著上调。抗体介导的体外功能实验表明，抑制CCDC45可降低癌细胞迁移能力，提示其作为治疗靶点的潜力。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词 **"CCDC45 antibody"** 或 **"CCDC45 AND (immunoblotting OR immunofluorescence)"**。部分研究可能聚焦于CCDC45的分子机制，并在方法学部分提及抗体使用。
The CCDC45 (Coiled-Coil Domain Containing 45) antibody is a tool used to detect and study the CCDC45 protein, which belongs to a family of proteins characterized by coiled-coil structural motifs. These motifs facilitate protein-protein interactions, suggesting CCDC45's involvement in cellular processes requiring molecular assembly or scaffolding. CCDC45 has been implicated in cilia-related functions, particularly in the formation and maintenance of motile cilia and flagella. Research links it to the intraflagellar transport (IFT) system, critical for ciliary structure and signaling. Dysregulation of ciliary proteins like CCDC45 is associated with ciliopathies, respiratory disorders, and infertility.
Antibodies against CCDC45 enable researchers to investigate its expression, localization, and interactions in tissues and cells. They are widely used in techniques such as immunofluorescence, Western blotting, and immunohistochemistry. Studies using CCDC45 antibodies have revealed its presence in ciliated tissues, including the respiratory epithelium and sperm flagella, supporting its role in ciliary motility. Recent work also explores its potential involvement in cancer progression, where altered ciliary function may influence tumor microenvironments.
Commercial CCDC45 antibodies are typically developed in rabbit or mouse hosts, with validation in model organisms like mice or humans. Their applications span basic research on cilia biology, disease mechanism studies, and diagnostic exploration for ciliopathy-related conditions. Ongoing research aims to clarify CCDC45's precise molecular interactions and therapeutic relevance.
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