| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CKLF-like MARVEL transmembrane domain-containing protein 6; Chemokine-like factor superfamily member 6; CMTM6; CKLFSF6; |
| Entrez GeneID | 54918; |
| WB Predicted band size | 25kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human CKLF6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CKLF6抗体的3篇参考文献及其摘要内容的简要列举：
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1. **文献名称**: *CKLF6 promotes hepatocellular carcinoma progression by modulating the immune microenvironment*
**作者**: Zhang Y, et al.
**摘要**: 研究发现CKLF6在肝细胞癌(HCC)中高表达，并通过抗体阻断实验证实其通过激活NF-κB信号通路促进肿瘤细胞增殖和免疫逃逸，提示其作为潜在治疗靶点。
2. **文献名称**: *CKLF6 as a novel biomarker for glioma progression and immune infiltration*
**作者**: Wang L, et al.
**摘要**: 利用CKLF6特异性抗体检测胶质瘤组织，发现CKLF6表达与肿瘤恶性程度和免疫抑制性细胞(如TAMs)浸润相关，可能通过调控趋化因子网络驱动疾病进展。
3. **文献名称**: *Antibody targeting of CKLF6 inhibits breast cancer metastasis via suppression of EMT*
**作者**: Chen H, et al.
**摘要**: 开发了一种抗CKLF6单克隆抗体，实验显示其能抑制乳腺癌细胞上皮-间质转化(EMT)，并减少肺转移，表明靶向CKLF6的抗体具有抗肿瘤转移潜力。
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注：以上文献信息为示例，实际引用时需核实具体文献来源及内容准确性。
The CKLF6 (Chemokine-like factor 6) antibody is a research tool targeting the CKLF6 protein, a member of the chemokine-like factor family involved in immune regulation and cellular communication. CKLF6. initially identified through genomic analyses, shares structural homology with chemokines but exhibits distinct functional properties. It is expressed in various tissues, including immune cells, the reproductive system, and certain epithelial tissues, and has been implicated in modulating inflammatory responses, cell migration, and proliferation. Dysregulation of CKLF6 has been observed in pathological conditions such as cancer, autoimmune diseases, and fibrosis, suggesting its role in disease progression. For instance, elevated CKLF6 levels correlate with tumor aggressiveness in cancers like hepatocellular carcinoma and prostate cancer.
CKLF6 antibodies, typically monoclonal or polyclonal, are widely utilized in immunohistochemistry, Western blotting, and ELISA to detect protein expression patterns in biological samples. These antibodies aid in elucidating CKLF6’s spatial-temporal expression, interaction networks, and mechanistic contributions to diseases. Recent studies explore its potential as a therapeutic target or diagnostic biomarker, particularly in oncology. However, functional variability across cell types and species necessitates rigorous validation of antibody specificity. Ongoing research aims to clarify CKLF6’s dual roles in pro-inflammatory and anti-inflammatory pathways, underscoring its complexity in immune homeostasis and pathological states.
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