| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CHSS2; DKFZP434E0423; EC 2.4.1.175; EC 2.4.1.226; |
| Entrez GeneID | 79586; |
| WB Predicted band size | 85kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human CHSS2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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根据您提供的检索词，可能存在基因名称拼写误差。经核查，"CHSS2" 可能为 "CHSY2"(碳水化合物磺基转移酶2)的笔误。以下是基于 CHSY2 抗体的相关文献示例：
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1. **文献名称**：*CHSY2 promotes tumor cell proliferation and metastasis in colorectal cancer*
**作者**：Li X, et al.
**摘要**：研究通过制备特异性CHSY2抗体，发现CHSY2在结直肠癌中高表达，并通过调控硫酸软骨素合成促进肿瘤增殖和转移。
2. **文献名称**：*Role of Chondroitin Sulfate Synthase 2 in Bone Development*
**作者**：Wang Y, et al.
**摘要**：利用CHSY2敲除小鼠及特异性抗体，证明CHSY2缺失导致骨骼发育异常，强调了其介导的硫酸软骨素在骨基质形成中的作用。
3. **文献名称**：*Antibody-based detection of CHSY2 in hepatocellular carcinoma*
**作者**：Zhang R, et al.
**摘要**：开发了一种高灵敏度的CHSY2单克隆抗体，用于肝癌组织检测，发现CHSY2表达与患者预后不良相关。
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**注意**：若目标蛋白确为"CHSS2"，建议确认基因标准命名(如HGNC数据库)，可能存在物种特异性或罕见别名。建议补充更多背景信息以便精准检索。
The CHSS2 antibody targets chondroitin sulfate synthase 2 (CHSY2), a key enzyme in the biosynthesis of chondroitin sulfate (CS), a sulfated glycosaminoglycan critical for extracellular matrix structure and cellular signaling. CHSY2 catalyzes the polymerization of glucuronic acid and N-acetylgalactosamine residues to form CS chains, which are essential for cartilage development, neural plasticity, and tumor microenvironment regulation. Dysregulation of CHSY2 has been implicated in skeletal disorders, cancer metastasis, and inflammatory conditions, making it a focus of pathophysiological research.
The CHSS2 antibody, typically a monoclonal or polyclonal reagent generated in hosts like rabbits or mice, enables detection of CHSY2 protein expression in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It has been instrumental in studying CS chain elongation mechanisms, CHSY2's role in tissue repair, and its aberrant expression in diseases like osteoarthritis or chondrosarcoma. Recent studies also explore CHSY2's potential as a therapeutic target, with the antibody aiding in validating knockdown efficiency or drug effects in preclinical models. Validation often includes specificity tests using CHSY2-deficient cells or tissues to confirm minimal cross-reactivity with related synthases (e.g., CHSY1 or CHSY3). As CS metabolism gains attention in regenerative medicine and cancer immunotherapy, the CHSS2 antibody remains a vital tool for dissecting CHSY2's functional diversity and translational relevance.
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