Rabbit Polyclonal CLCNKA Antibody

The CLCNKA antibody targets the CLC-Ka protein, a member of the CLC family of chloride channels or Cl⁻/H⁺ exchangers. Encoded by the *CLCNKA* gene in humans, CLC-Ka is primarily expressed in renal tissues, particularly the thin ascending limb of Henle's loop and the collecting duct, where it facilitates chloride ion transport. It plays a critical role in urine concentration and electrolyte balance. CLC-Ka requires barttin, a β-subunit, for proper membrane trafficking and functional activity. Mutations in *CLCNKA* or its partner gene *BSND* (encoding barttin) are linked to Bartter syndrome type IV, a rare renal disorder characterized by salt wasting, hypokalemia, and metabolic alkalosis. Antibodies against CLCNKA are essential tools for studying its expression, localization, and interaction with barttin in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate renal channelopathies, drug development targeting electrolyte disorders, or mechanisms of ion transport regulation. Research using CLCNKA antibodies also explores its potential role in hearing, as CLC-K channels in the inner ear contribute to endolymph homeostasis.